ABSTRACT:
Conventional oral dosage form has little or no control over the drug release, and effective concentration at the target site. Such kind of dosing pattern may results in constantly changing, unpredictable plasma concentrations. The rate and extent of drug absorption from conventional formulations may vary greatly depending on the factors such as- A] Physio-chemical properties of the drug, B] Presence of excipient, C] Physiological factors such as presence or absence of food, D] pH of the gastro-intestinal tract (GI) and so on. The majority of controlled release dosage forms systems are matrix-based, and their principal drug release mechanism is based on drug diffusion through the matrix system. This is altered by- 1] The pH of the medium, 2] Presence of food, 3] The body’s physiological factors (G.I. motility). All these factors also responsible for release of aceclofenac from conational dosage form. Osmotic systems use the principle of osmosis as delivery force to deliver the drug from the system, and the release rate is unaffected by the body’s pH and other physiological factors. So, the objective of the present work was to design osmotically driven oral drug delivery system containing aceclofenac as an active ingredient which is most beneficial for patients with long term treatment of NSAID’s.