Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Design and Evaluation of Taste Masked Fast Disintegrating Tablet of Racecadotril

Author(s): Gautam Singhvi, Mahaveer Singh, Gunja Chaturvedi, Sohiny Sharma, Kapil Yadav

Email(s): singhvigautam@gmail.com

DOI: Not Available

Address: Gautam Singhvi*, Mahaveer Singh, Gunja Chaturvedi, Sohiny Sharma and Kapil Yadav
Pharmacy Group, Birla Institute of Technology and Science, Pilani. (Rajasthan)
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

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ABSTRACT:
Racecadotril is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor. racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine.The aim of this study was to prepare, using taste masked granules, rapidly disintegrating tablets of Racecadotril, a bitter drug. The taste masked granules were prepared by solid dispersion technique and with polymeric granulation. In vitro release profile obtained at pH 6.8 indicate that perceivable amount of drug will not be released in saliva while high percent release (more than 75% in 60 min) would be obtained at pH 4.5. These taste masked granules were directly compressed into tablets using sodium starch glycolate as a super-disintegrant. The prepared tablets containing the taste masked granules having sufficient strength of 3.5 kg/cm were evaluated disintegration time, drug content, in-vitro release parameters. Developed formulation is more patient compliance dosage forms.


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Cite this article:
Gautam Singhvi, Mahaveer Singh, Gunja Chaturvedi, Sohiny Sharma, Kapil Yadav. Design and Evaluation of Taste Masked Fast Disintegrating Tablet of Racecadotril. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1050-1052.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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