Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Plant Derived Ribosome Inactivating Proteins: An Overview

Author(s): Nitin Kumar, Satyendra Singh, Manvi, Rajiv Gupta

Email(s): rajiv961@rediffmail.com

DOI: Not Available

Address: Nitin Kumar, Satyendra Singh, Manvi and Rajiv Gupta*
Department of Pharmacognosy, Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow 227 105 U.P (India)
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

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ABSTRACT:
Many plants accumulate proteins that are commonly referred to as ribosome-inactivating proteins (RIPs). Biological effects described to these proteins go back to ancient times because of the high toxicity of seeds of castor bean (Ricinus communis) and jequirity bean (Abrus precatorius), as well as anti-HIV, the abortifacient activity of some plants like Trichosanthes kirilowii and Momordica charantia, rely on the presence of RIPs. Pokeweed antiviral protein, and ricin, previously described as ribosome-inactivating proteins were shown to damage single-stranded DNA by removal of a protein-specific set of adenines. RIPs are enzymes and some have multiple enzymatic activities. These enzymes are expected to damage DNA rather than participate in repair processes. All RIPs depurinated DNA extensively and some released adenine from all adenine-containing polynucleotides. The entire class of plant proteins, called ribosome-inactivating proteins, may be classified as polynucleotide: adenosine glycosidases. The significance of this DNAase activity to the biological function of these plant proteins along with their toxicity effect to animal cells remains to be fully understood.


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Cite this article:
Nitin Kumar, Satyendra Singh, Manvi, Rajiv Gupta. Plant Derived Ribosome Inactivating Proteins: An Overview. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1018-1022.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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