Chandak BG, Sarpate RV, Chatterjee NR, Baheti KG
Chandak B.G.1*, Sarpate R.V.1 , Chatterjee N.R.2 and Baheti K.G.2
1Siddhant College of Pharmacy, Sudumbare, Pune. 2Department of Pharmaceutical Chemistry, Pad Dr. D.Y. P. College of Pharmacy, Akurdi, Pune-411044
Volume - 3,
Issue - 3,
Year - 2010
An efficient method for green synthesis of some 2, 3-dihydro 1H-1, 5-benzodiazepine derivatives has been developed by simple cyclocondensation reaction of o-phenylendiamine with aromatic, cyclic and acyclic ketones as well as 1, 3-ß dicarbonyl compounds in presence of catalytic amount of silica gel under ultrasound irradiation. The title compounds have been characterized by physico-chemical methods and screened for anti-microbial activity in order to evaluate for the effectivity against Crofloxin and Ciclopiroxoamine as standard.
Cite this article:
Chandak BG, Sarpate RV, Chatterjee NR, Baheti KG. Synthesis, Spectral Studies and Biological Activity of Some 1, 5-Benzodiazepine Derivatives. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 938-941.