Author(s): Subhendu Mishra, Prashant Y Mali, Asha Kesri, Asit Sahu, Bibhu Mishra, Bhupendra Behera

Email(s): sekhar.subhendu@gmail.com

DOI: Not Available

Address: Subhendu Mishra1*, Prashant Y. Mali1, Asha Kesri2, Asit Sahu2, Bibhu Mishra3 and Bhupendra Behera3
1Radharaman College of Pharmacy, Ratibad, Bhopal-462044 (M.P.), India.
2Department of Pharmaceutics, Kanak Manjari Institute of Pharmaceutical Sciences, Chhend, Rourkela- 769015(Orissa), India.
3Department of Pharmaceutics, Gayatri College of Pharmacy, Sambalpur-768004 (Orissa), India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
The aim of present study was formulation and in-vitro evaluation of fast dissolving tablets of paracetamol by using direct compression technique. Paracetamol fast dissolving tablets was formulated using various concentrations (2%, 3%, 4% and 5%) of superdisintegrants like Crosscarmellose sodium (CCS) and Microcrystalline cellulose (MCC). The excipients used in these formulations not only aid fast disintegration of tablets, but also mask the slight better taste of drug. Tablets imparted patient benefits and increased consumer satisfaction, despite the different mechanisms involved in these technique. All the formulation batches were prepared by direct compression method using Lab CIT multi punch tablet compression machine using 8 mm flat punch. The prepared tablets were evaluated for weight variation, hardness, thickness, friability, disintegration time, drug content and dissolution study. The tablets show acceptable weight variations as per pharmacopoeial specifications. Friability shows below 1% indicating a good mechanical resistance of tablets. The CCS at the concentration 3% (F3) shows fast disintegration in 23 sec. and 99.9% drug release in 300 sec. was selected as an optimized formulation. Thus, CCS can be successfully used in the formulation of fast disintegrating tablets of paracetamol. The formulation was stable under accelerated conditions of temperature and humidity.


Cite this article:
Subhendu Mishra, Prashant Y Mali, Asha Kesri, Asit Sahu, Bibhu Mishra, Bhupendra Behera. Formulation and In-Vitro Evaluation of Fast Dissolving Tablets of Paracetamol by Direct Compression Technique. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 934-937.


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