Author(s): Gitika Dhingra, Brinda Sreelesh, Manju Nagpal, Pankaj Rakha, B P Nagori

Email(s): gitu2k2@rediffmail.com

DOI: Not Available

Address: Gitika Dhingra1*, Brinda Sreelesh1, Manju Nagpal2, Pankaj Rakha3, and B. P. Nagori4
1NCRD’s Sterling Institute of Pharmacy, Nerul, Navi Mumbai-400706.
2Chitkara School of Pharmacy, Chitkara University, Solan-174103 (HP)
3Rajendra Institute of Technology and Sciences, Sirsa-125055 (Haryana)
4Lachoo Memorial College of Science and Technology, Jodhpur (Rajasthan)
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
In present study, the performance of biorelevant and compendial dissolution media was compared to test dissolution of drugs belonging to class II according to Biopharmaceutic Classification Scheme (BCS). The solubility of Ibuprofen, a weakly acidic drug, was determined in various media (water, Phosphate buffer pH 7.2, FaSSIF and FeSSIF) having different pH to calculate D/S values in different media. Invitro dissolution of marketed tablets was studied in compendial media (water, phosphate buffer pH 7.2) and biorelevant media (FaSSIF and FeSSIF). Dissolution of Ibuprofen was found to be dependent upon pH. In all cases, the mean dissolution profiles in biorelevant media were in concordance with in vivo findings published earlier. The method was validated in terms of linearity and precision. The similarity factor in different media was also evaluated.


Cite this article:
Gitika Dhingra, Brinda Sreelesh, Manju Nagpal, Pankaj Rakha, B P Nagori. In-Vitro Dissolution Testing of Ibuprofen Using Compendial and Biorelevant Dissolution Media. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 931-933.


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DOI: 10.5958/0974-360X 

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