S Jeganath, S Palanichamy, S H Seyed Mohamed Buhary, P Solai Raj, C Prabhu, A Thanga Thrupathi
S. Jeganath1, S. Palanichamy1, S. H. Seyed Mohamed Buhary1*, P. Solai Raj2,
C. Prabhu1 and A. Thanga Thrupathi3
1Department of Pharmaceutics
2Department of Pharmaceutical Analysis
3Department of Pharmacology, Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam, Sivakasi – 626130, Tamilnadu, India.
Volume - 3,
Issue - 3,
Year - 2010
In the present study, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance by developing controlled release (CR) tablets of silymarin. The CR tablets of silymarin were prepared by direct compression method. Three formulations containing different concentration of drug and polymer in the ratio of (1:0.25) (1:0.5) and (1:0.75) were prepared. The formulated tablets were compared with the marketed sample. The evaluation tests for powder blends are angle of repose, bulk density, tapped density, compressibility index and hausner’s ratio. The powder blend contains good flow character. Tablets were evaluated for various parameters such as thickness, hardness, friability, drug content, weight variation, stability studies and invitro release studies. The proportion of the polymer showed significant difference in the release of the drug.
Cite this article:
S Jeganath, S Palanichamy, S H Seyed Mohamed Buhary, P Solai Raj, C Prabhu, A Thanga Thrupathi. Formulation and Evaluation of Silymarin Controlled Release Tablets. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 927-930.