Design and Evaluation of Oral Controlled Release Matrix Tablets of Zidovudine

Amit S Yadav; Ashok Kumar P; Suresh V Kulkarni; Someshwara Rao B; Sumanta Malakar

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

Submit Article

Design and Evaluation of Oral Controlled Release Matrix Tablets of Zidovudine

Author(s): Amit S Yadav, Ashok Kumar P, Suresh V Kulkarni, Someshwara Rao B, Sumanta Malakar

Email(s): ashokkumarscp@yahoo.com

DOI: Not Available

Address: Amit S. Yadav, Ashok Kumar P.*, Suresh V. Kulkarni, Someshwara Rao B. and Sumanta Malakar
Dept. of Pharmaceutics, Sree Siddaganga College of Pharmacy, B. H. Road, Tumkur-572102, Karnataka, India.
*Corresponding Author

Published In: Volume - 3, Issue - 3, Year - 2010

View HTML

View PDF

ABSTRACT:
Oral controlled release matrix tablets of zidovudine were prepared by wet granulation technique using ethyl cellulose. The effect of the concentration of the polymer was studied. The studies indicated that the drug release can be modulated by varying the concentration of the polymer. The prepared tablets were evaluated for various physiochemical parameters by official procedures. The in vitro release study of matrix tablets were carried out in phosphate buffer pH 6.8 for 12 hours. The prepared matrix tablets were shown 98.42%, 96.52%, 88.90%, 82.21%, and 73.76% release over a period of 12 hours. Among all the formulation, F2 shows 96.52% release at the end of 12 hours. Selected formulation (F2) was subjected to stability studies for three months, which showed stability with respect to release pattern. The release data was fitted to various mathematical models such as, Higuchi, Korsmeyer-Peppas, First-order, and Zero-order to evaluate the kinetics and mechanism of the drug release. The release profile of the developed formulations was described by the Higuchi model and the mechanism was found to be an anomalous (non-fickian) diffusion transport mechanism.

Keywords:

Cite this article:
Amit S Yadav, Ashok Kumar P, Suresh V Kulkarni, Someshwara Rao B, Sumanta Malakar. Design and Evaluation of Oral Controlled Release Matrix Tablets of Zidovudine. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 917-920.

Recomonded Articles:

Formulation of PLGA Polymeric Nanosuspension containing Pramipexole Dihydrochloride for improved treatment of Parkinson’s Diseases

Author(s): I. Somasundaram, B.V. Nagarjuna Yadav, S. Sathesh Kumar

DOI: 10.5958/0974-360X.2016.00155.4 Access: Open Access Read More

Formulation and Evaluation of Aspirin Tablets by Using Different Lubricants in Combination for better Kinetic Drug Release Study by PCP

Author(s): Pawan Singh, Prevesh Kumar, Neelkant Prasad

DOI: 10.5958/0974-360X.2017.00519.4 Access: Open Access Read More

Formulation and Evaluation of Sustained Release Floating Matrix Tablets of Labetalol Hydrochloride.

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Sustained Release Matrix Tablets of Pregabalin

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Extended Release Matrix Formulation of Metoprolol Succinate

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available Access: Open Access Read More

An overview on the established pharmaceutical aspects associated with the development of hydrogels

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1 Access: Open Access Read More