Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Analgesic and Anti-Inflammatory Activities of Datura metel Linn. Root in Experimental Animal Models.

Author(s): P Muthusamy, M Nivedhitha, N Jayshree

Email(s): muthu_p99@yahoo.com

DOI: Not Available

Address: P. Muthusamy*, M. Nivedhitha and N. Jayshree
Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-600 003.
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010

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ABSTRACT:
Datura metel (Syn: D. fastusa) [Family: Solanaceae] were extracted with ethanol and evaluated for its analgesic and anti-inflammatory effects by employing various models such as acetic acid-induced writhing test, tail immersion test, hotplate method and carrageenan induced paw edema tests. The extract at 200 and 400 mg / kg concentration significantly (p<0.001) reduced the number of writhes produced by acetic acid (0.6 %) and significantly increased the reaction time in thermal models such as hot water tail immersion, hot plate method (p<0.001). There was a significant reduction in the paw volume in the animals treated with D. metel extract (p<0.001). Aspirin (100 mg/kg), Pentozicine (5 mg / kg) and Indomethacin (10 mg /kg) were employed as the standard drugs for comparison. The results of the present study revealed that the ethanolic extract of roots of Datura metel exhibits a potential analgesic and anti-inflammatory effects.


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Cite this article:
P Muthusamy, M Nivedhitha, N Jayshree. Analgesic and Anti-Inflammatory Activities of Datura metel Linn. Root in Experimental Animal Models. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 897-899.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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