Author(s): P Muthusamy, M Nivedhitha, N Jayshree

Email(s): muthu_p99@yahoo.com

DOI: Not Available

Address: P. Muthusamy*, M. Nivedhitha and N. Jayshree
Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-600 003.
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
Datura metel (Syn: D. fastusa) [Family: Solanaceae] were extracted with ethanol and evaluated for its analgesic and anti-inflammatory effects by employing various models such as acetic acid-induced writhing test, tail immersion test, hotplate method and carrageenan induced paw edema tests. The extract at 200 and 400 mg / kg concentration significantly (p<0.001) reduced the number of writhes produced by acetic acid (0.6 %) and significantly increased the reaction time in thermal models such as hot water tail immersion, hot plate method (p<0.001). There was a significant reduction in the paw volume in the animals treated with D. metel extract (p<0.001). Aspirin (100 mg/kg), Pentozicine (5 mg / kg) and Indomethacin (10 mg /kg) were employed as the standard drugs for comparison. The results of the present study revealed that the ethanolic extract of roots of Datura metel exhibits a potential analgesic and anti-inflammatory effects.


Cite this article:
P Muthusamy, M Nivedhitha, N Jayshree. Analgesic and Anti-Inflammatory Activities of Datura metel Linn. Root in Experimental Animal Models. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 897-899.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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