Author(s): M Sheeba rani, S Emmanuel, M Raja Sreekanth, T Rosemary

Email(s): emmasj23@yahoo.com

DOI: Not Available

Address: M. Sheeba Rani, S. Emmanuel* and M. Raja Sreekanth Department of Agricultural Science, Loyola Academy, Old Alwal, Secunderabad-500 010. *Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
This study was aimed to evaluate the Anti-inflammatory and Antipyretic activities of the methanol fraction and its pure compound chrysophanol of Cassia occidentalis Linn. in male albino wistar rats. Paw edema was produced by subplantar injection of carrageenan, cotton pellet granuloma was produced by implantation of 30 mg sterile cotton in groin region. The animals were treated with methanol fraction COMF (200 mg/kg bw) and chrysophanol (30 mg/kg bw). The results showed that COMF and chrysophanol significantly inhibited inflammation in carrageenan induced paw edema and cotton pellet granuloma models (p>0.05). Fever was induced by yeast-induced hyperpyrexia. In chrysophanol treated groups the mean temperature 38.04°C was reduced to 36.33°C at 3 h and 35.98oC at 4 h. Interestingly the COMF, also showed maximum reduction in temperature, from 38.22°C to 37.01 °C at 3 h and 36.61°C at 4 h. The temperature lowering activity of COMF and chrysophanol (P>0.05) was similar to paracetamol treated group. In conclusion, this study has established the anti-inflammatory activity and antipyretic activity of C. occidentalis, justifies the ethnic uses of the plant.


Cite this article:
M Sheeba rani, S Emmanuel, M Raja Sreekanth, T Rosemary. Evaluation of the Antipyretic and Anti-inflammatory Activities of Methanolic Fraction and Chrysophenol of Cassia occidentalis Linn. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 888-893.


Recomonded Articles:

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): M.A. Saleem, Raghavendra V. Kulkurni, Patil Noornadim G

DOI: Not Available         Access: Open Access Read More

Author(s): DK Golwala, LD Patel, SB Bothara, SK Vaidya, AR Sahu, S Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB

DOI: Not Available         Access: Open Access Read More

Author(s): S. R Suseem, Dhanish Joseph

DOI: 10.5958/0974-360X.2019.00067.2         Access: Open Access Read More

Author(s): Sahu Sudeep, Dey Tathagata, Khaidem Somila, Y Jyothi

DOI: Not Available         Access: Open Access Read More

Author(s): Soumya Khare, Amit Alexander, Ajazuddin, Nisha Amit

DOI: Not Available         Access: Open Access Read More

Author(s): Suralkar Anupama A., Jadhav Asha S., Vaidya Gayatri S., Sharma Ashish, Meghraj Chaudary, Vivek Bhora

DOI: Not Available         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags