Author(s): Sanat Kumar Basu, Kunchu Kavitha, Mani Rupeshkumar

Email(s): kaviyaju@yahoo.co.in

DOI: Not Available

Address: Sanat Kumar Basu1, Kunchu Kavitha2* and Mani Rupeshkumar3
1Division of Pharmaceutics, Dept. of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, India.
2Dept. of Pharmaceutics, Bharathi College of Pharmacy, Bharathi Nagara, Mandya Dist, Karnataka -571 422, India.
3Dept. of Pharmacology, Bharathi College of Pharmacy, Bharathi Nagara, Mandya Dist, Karnataka - 571 422, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
Microspheres (MS) of Tramadol Hydrochloride (TM) were prepared by coacervation method without the use of chemical cross–linking agent (glutaraldehyde) to avoid the toxic reactions and other undesirable effects of the chemical cross-linking agent. Alternatively, ionotropic gelation was employed by using sodium-tripolyphosphate (Na-TPP) as cross linking agent. Chitosan was used as polymer. All the prepared microspheres were subjected to various physico-chemical studies, such as drug-polymer compatibility by thin layer chromatography (TLC) and Fourier Transform Infrared Spectroscopy (FTIR), surface morphology by scanning electron microscopy (SEM), frequency distribution, encapsulation efficiency by High Performance Thin Layer Chromatography (HPTLC), in-vitro drug release characteristics and release kinetics. TLC and FTIR studies indicated no drug-polymer incompatibility. Surface smoothness of MS was increased by increasing the polymer concentration, which was confirmed by SEM. As the drug to polymer ratio was increased, the mean particle size (MPS) of TM microspheres was also increased. A maximum of 87% of drug entrapment efficiency was obtained by the method employed. All the MS showed initial burst release followed by a Fickian diffusion mechanism. It is possible to design a controlled drug delivery system for the prolonged release of TM, improving therapy by possible reduction of time intervals between administrations.


Cite this article:
Sanat Kumar Basu, Kunchu Kavitha, Mani Rupeshkumar. Formulation and Evaluation of Tramadol Hydrochloride Microspheres for Oral Delivery. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 877-881.


Recomonded Articles:

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao US, San San Oo, Nurul Liana Sabrin, Norsyahira Syazwana Mohd Razali, Khairunnisa Khalid, Nurul Farihah Mohamed Nadzari, Thant Zin

DOI: 10.5958/0974-360X.2017.00065.8         Access: Open Access Read More

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3         Access: Open Access Read More

Author(s): Amutha K*, Ashok Kumar A, Godavari A

DOI: 10.5958/0974-360X.2017.00100.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags