Obsessive-Compulsive Disorder (OCD) is characterized by absurd, recurrent thoughts (obsessions) followed by certain stereotyped actions (compulsions). The thoughts and behaviors associated with OCD are viewed as senseless, and egodystonic and they stand contradictory to the individual’s motives, goals, identity, and self-perception thereby creating significant subjective distress. Entire brain functioning is disturbed in patients suffering from OCD, thereby producing devastating effects at the work-place as well as at homes of the patients. Marble-burying behavior of mice is a well-accepted paradigm to screen anti-compulsive activity. Only potent serotonin reuptake inhibitors (SSRIs) are consistently effective in patients of obsessive–compulsive disorder. The aim of this study was to test the efficacy of different psychoactive agents like venlafaxine (bicyclic antidepressant), diazepam (anxiolytic) and chlorpromazine (antipsychotic) on marble-burying behavior of mice. In the present study, chronic administration of venlafaxine (30 mg kg-1 i.p.) showed significant anti-compulsive effect, causing statistically significant inhibition of marble-burying behavior of mice. Diazepam (2.5 mg kg-1 i.p.) on chronic administration showed significant anti-compulsive, as reflected by attenuation of marble-burying behavior of mice. Chlorpromazine (3 mg kg-1 i.p.) showed anti-compulsive effect, as reflected by inhibition of marble-burying behavior of mice.
Cite this article:
Uday Gaikwad, Milind Parle. Effects of Different Psychoactive Agents on Marble-Burying Behavior in Mice. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 865-868.