Author(s): P Kumar, R Tiwari, B Chaurasia, RR Sahu, FM Tripathi, Anjana Bhardhwaj

Email(s): rahul.tiwari.pharm@gmail.com

DOI: Not Available

Address: P. Kumar, R. Tiwari*, B. Chaurasia, R.R. Sahu, F.M. Tripathi and Anjana Bhardhwaj
Department of Pharmaceutics, RKDF College of Pharmacy, Bhopal (India)
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
The objectives of the present investigation were optimization and formulation development of Propranolol HCl multi-particulate beads and their comparison with the marketed formulation. Different drug: polymer ratio were taken and optimized for the best possible drug release. Various processes controlling like load, fluidization, total polymer content, atomization pressure, and spray rate were optimized. Extrusion spheronisation was done to prepare core pellets containing drug. Micro Crystalline Cellulose was selected as a spheronizing agent and Hydroxy Propyl Methyl Cellulose used as binder. Binder concentration 2.5% was showing the optimum release and good spherical shape core pellets. Coating was done by ethyl cellulose (EC) N50: HPMC in ratio of 70:30 and Triethyl citrate (10% of EC) as plasticizer. The release profile of optimized formulation and MF was similar and confirmed by calculation of two factors i.e. differential factor (F2; 71.85) and similarity factor (F1; 9.15).


Cite this article:
P Kumar, R Tiwari, B Chaurasia, RR Sahu, FM Tripathi, Anjana Bhardhwaj. Multi Particulate Extended Release Formulation for Propranolol Hydrochloride. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 835-839.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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