Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari
Avinash Bhagwat1*, Suhas M. Kakade2, Chirag V. Naval2, Mukesh Tilker1, Ravindra M. Walture3, Sagar A. Adichwal2 and Atul P. Chaudhari4
1Department of Pharmaceutical Chemistry, K.L.E. University’s College of Pharmacy, J.N.M.C. Campus, Belgaum-590010, India.
2Department of Pharmaceutics, K.L.E. University, J.N.M.C. Campus, Belgaum-590010, India.
3Deparment of pharmacology, K.L.E. University, J.N.M.C. Campus, Belgaum-590010, India.
4Smt. S. S. Patil Institute of Pharmacy, Chopda-425107, Jalgaon, India.
Volume - 3,
Issue - 3,
Year - 2010
In the present work, mouth dissolving tablets of domperidone were design with a view to enhance the patient compliance and provide a quick onset of action. Domperidone is antiemetic dopamine receptor antagonist and it has long half life. The purpose of this study mouth dissolving tablets rapidly disintegrate in oral cavity and increase the dissolution so that the drug attains the therapeutic level in short time, so elicits better pharmacological effects. Mouth dissolving tablets prepared by direct compression and using super disintegrants like sodium starch glycolate, croscarmellose sodium and crospovidone in different concentration and evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among all, the formulation containing 5%w/w superdisintegrant crospovidone was considered to be best formulation, which release up to 98.15% in 15min.
Cite this article:
Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari. Formulation and Evaluation of Mouth Dissolving Tablets of Domperidone. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 821-824.