Design and Evaluation of Nimesulide Lozenges for Pediatrics

Mohd Yousuf Ali; Md Shamim Qureshi; Md Hamed; Byasabhusan Das and K Purushotham Rao

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

Submit Article

Design and Evaluation of Nimesulide Lozenges for Pediatrics

Author(s): Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao

Email(s): drsmileforu_433@yahoo.com

DOI: Not Available

Address: Mohd. Yousuf Ali*1, Md. Shamim Qureshi1, Md. Hamed1, Byasabhusan Das1 and K. Purushotham Rao2
1Dept. of Pharmaceutics, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad 500001, India.
2Dept. of Pharmaceutics, HKE Society’s College of Pharmacy, Gulbarga-585105, Karnataka, India
*Corresponding Author

Published In: Volume - 3, Issue - 3, Year - 2010

View HTML

View PDF

ABSTRACT:
Most of the illnesses are associated with fevers, headache and body aches and it is very difficult for parents to manage pediatric patients to administer the drug dosage forms. In the present investigation, an attempt has been made to formulate medicated sugar based tablet lozenges for kids using Nimesulide as model drug, which is commonly used analgesic and anti-pyretic. There are many dosage forms available in the market but still there is a need for new dosage form which acts effectively. So the present investigation has been taken up to design, prepare and evaluate hard candy based medicated tablet lozenges to meet the need of improved action dosage form. All the formulations prepared were subjected to various physico- chemical parameters such as hardness, drug content uniformity, weight variation, moisture content etc. The prepared formulations have a hardness of 9-12 Kg/cm2, not gritty, mouth feel freshness taste. Stability studies of selected formulations were also carried out at 37oC and 45oC for a period of six months. Formulations were tested for drug excipient interactions subjecting to IR Spectral analysis. In-vitro drug dissolution studies showed 97.62% for F0 formulation in 15 Minutes and 85.04% for F1 formulation release of drug in 30 minutes. The hard boiled candy lozenges can provide an attractive alternative formulation in the treatment of pain and fever in pediatrics.

Keywords:

Cite this article:
Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao. Design and Evaluation of Nimesulide Lozenges for Pediatrics. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 818-820.

Recomonded Articles:

Qualitative Phytochemical Screening and In-vitro Anthelmintic Activity of Adhatoda vasica (Acanthaceae)

Author(s): Shabi Ruskin, R., S. Ajina

DOI: 10.5958/0974-360X.2017.00083.X Access: Open Access Read More

Design and Evaluation of Nimesulide Lozenges for Pediatrics

Author(s): Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao

DOI: Not Available Access: Open Access Read More

Phytochemistry, Traditional uses and Pharmacology of Rhododendron arboreum: A Review

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6 Access: Open Access Read More

Varicella zoster: Etiology, Pathogenesis and Basic Principles of Treatment

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3 Access: Open Access Read More

Nilavembukudineer awareness for Dengue and Chicken Gunia among Rural Community people in Tamil Nadu

Author(s): Shahana R. Y., Lakshmi. T

DOI: 10.5958/0974-360X.2016.00433.9 Access: Open Access Read More

In-Vitro and In-Vivo Correlation of Marketed Formulation of Nimesulide

Author(s): Kuldeep Malodia, Sunil Kumar, Pankaj Rakha, SK Singh, DN Mishra

DOI: Not Available Access: Open Access Read More

Herbal Remedies for Swine Flu

Author(s): Sahil Choudhari, Vishnu Priya .V, R. Gayathri

DOI: 10.5958/0974-360X.2016.00362.0 Access: Open Access Read More

A Review on – Dengue

Author(s): Rasana Patil, Tina Makhija, H. P. Suryawanshi, S.P. Pawar

DOI: Not Available Access: Open Access Read More

Dissolution Profiling of Bilayered Conventional Release Paracetamol and Sustained Release Ibuprofen (By Simultaneous Estimation Method UV)

Author(s): Pankaj P. Ostwal, Yogesh L. Jadhav, Mayur S. Jain, Sumit P. Jain

DOI: Not Available Access: Open Access Read More

Dillenia indica: A Review on Morphology, Phytochemistry and Pharmacological Aspects

Author(s): Padmavathi D., Netravati Deshpande, Sarala A.

DOI: Not Available Access: Open Access Read More

A Pilot Study on Evaluation of Self-Medication among Undergraduate Medical Students in Dhaka, Bangladesh

Author(s): Abu Syed Md. Mosaddek, Zakirul Islam, Md. Faizur Rahman, Md. Shakil Akter, Jahanara Laizu, Roksana Parvin, Noor E Tabassum, Nordin Bin Simbak, Mainul Haque

DOI: Not Available Access: Open Access Read More

Central Nervous System Depressant and Analgesic Activity of Methanolic Extract of Drypetes roxburghii Wall in Experimental Animal Model

Author(s): Sudharshan SJ, Chinmaya A, Valleesha NC, Prashith Kekuda TR, Rajeshwara AN, Syed Murthuza

DOI: Access: Open Access Read More

Benincasa hispida: A Natural medicine

Author(s): Manoj S. Pagare, Leena Patil, Vilasrao J. Kadam

DOI: Not Available Access: Open Access Read More

Screening of Analgesic and Anti-inflammatory Activity of Hydroalcohol Extract of Sida (Indian) Species Root

Author(s): VH Bhaskar, B Sangameswaran, N Balakrishnan, AB Panda, Navin R Raj, A Sathish

DOI: Access: Open Access Read More

Dietary Soups to Avert and Recuperate from Dengue Fever

Author(s): A. Arun, S. Kanimozhi, M. Vijayakumar

DOI: 10.5958/0974-360X.2019.00715.7 Access: Open Access Read More

Preliminary phytochemical analysis of Acacia catechu willd Heartwood extract

Author(s): Anitha Magesh1 and Lakshmi T.2

DOI: Not Available Access: Open Access Read More

Formulation and in vitro comparative evaluation of orodispersible tablets of Pantoprazole

Author(s): Srinivasa DS, Narayana Charyulu R, Satyanarayana DS, Srilakshmi D

DOI: 10.5958/0974-360X.2015.00249.8 Access: Open Access Read More

Elevation of Temperature after General Anaesthesia following Dental Treatment with or without the use of Prophylactic Antibiotics in Children

Author(s): B. Ssneha, Deepa Gurunathan

DOI: 10.5958/0974-360X.2016.00025.1 Access: Open Access Read More

Triple Combination Antiviral Therapy

Author(s): Kaur Simaranjit, Kaur Kuldeep, Kaur Herbaksh

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Ascorbic acid Lozenges for the treatment of Oral Ulcer

Author(s): Akansha Bhandarkar, Amit Alexander, Aditi Bhatt, Pankaj Sahu, Palak Agrawal, Tripti Banjare, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Hemlata Thapa, Deepika, Vinay Sagar Verma, Mukesh Sharma, D. K. Tripathi, Ajazuddin

DOI: 10.5958/0974-360X.2018.00243.3 Access: Open Access Read More