P K Mohanty, P K Panda, V J Patro, S K Panda, C M S Panda
P. K. Mohanty1*, P. K. Panda2, V. J. Patro3, S. K. Panda² and C. M. S. Panda2
1Sri Satya Sai college of Pharmacy, Sehore, M.P.
2Dept. of Pharmacy, Utkal University Bhubaneswar, 754004
3College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa.
Volume - 3,
Issue - 3,
Year - 2010
Methanolic extract of Cassia angustifolia bark was tested for its anti gastric ulcer and compared with anti ulcer of ranitidine in shay rat model. Oral dose with 5mg/kg body weight of ranitidine showed complete absence of ulceration in shay rats. The anti gastric ulcer activity of Cassia angustifolia Methanolic extract (800mg/kg) body weight was found equal to the effect produced by 5mg/kg Ranitidine in this model. Oral administration of methanol extract (800 Mg. /Kg) Cassia angustifolia bark showed complete inhibition of ulceration and significant reduction in free acidity, Total acidity peptic activity and volume of gastric juice secreted were found.
Cite this article:
P K Mohanty, P K Panda, V J Patro, S K Panda, C M S Panda. Antiulcer Activity of Methanolic Extract of Cassia angustifolia Bark and Its Comparison with Ranitidine in Shay Rat. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 812-814.