Author(s): Kalpana Vasanthan, R Vijayageetha, A Shantha Arcot

Email(s): kalpana.vasanthan@gmail.com

DOI: Not Available

Address: Kalpana Vasanthan*, R. Vijayageetha and A. Shantha Arcot
Department of Pharmaceutical Analysis, C. L. Baid Metha College of Pharmacy, Jyothinagar, Thoraipakkam .Chennai-600 097, Tamilnadu, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
A rapid, simple, precise and sensitive RP-HPLC method was developed for estimation of nateglinide in pharmaceutical bulk drug and pharmaceutical formulation. A phenomenex Gemini C18, 5µm particle size column having 250 x 4.6 mm .i.d in isocratic mode, with mobile phase containing acetonitrile: 0.1%w/v sodium dihydrogen ortho phosphate (70:30v/v) was used. The flow rate was 2ml/min and the effluent was monitored at 220nm. The retention time of nateglinide was 6.7±0.2 minutes. The method was validated for linearity, accuracy, precision, specificity, LOD, LOQ and robustness. Nateglinide showed linear response in the concentration range 160-240µg/ml. the correlation coefficient for nateglinide was 0.9999 and the percentage recovery was found to be 99.26to 100.81.


Cite this article:
Kalpana Vasanthan, R Vijayageetha, A Shantha Arcot. Method Development and Validation of RP-HPLC Method for Estimation of Nateglinide in Bulk Drug and Pharmaceutical Formulation. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 804-806.


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DOI: 10.5958/0974-360X 

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