ABSTRACT:
The present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of Losartan Potassium (LP) using blends of two different polymers i.e. Povidone (PVP) and Ethylcellulose (EC). Drug-excipients interaction studies were carried out using Fourier transform infrared spectroscopy (FTIR). All the formulations were found to be suitable for formulating in terms of physicochemical characteristics and there was no significant interaction observed between the drug and polymers used. Drug patches of polymers were prepared by solvent casting method employing methanol as a solvent. These patches were evaluated for weight and thickness uniformity, moisture content, moisture uptake, content uniformity and in-vitro skin permeation study was conducted in a modified Franz’s diffusion cell. Formulated patches in each group are uniform in drug distribution and are transparent in appearance. Amongst the different formulations, batch of EC:PVP patches in a ratio of 2:3 was found to provide the maximum in-vitro release of drug. Thus this batch was selected to study the effect of plasticizers. Amongst the plasticizer used dibutyl phthalate (DBP) at 10% w/w with respect to polymer weight was found to be the better plasticizer than Triethyl citrate (TEC).