Author(s): Ganesan V, Lokesh Mangalmurti Chitrivekar

Email(s): sankarv_2003@yahoo.co.in

DOI: Not Available

Address: Ganesan V1* and Lokesh Mangalmurti Chitrivekar2
1Swamy Vivekanandha College of Pharmacy,Elayampalayam-637 205,Tiruchengode,Namakkal-Dist,(TN)India
2Sankaralingam Bhuvaneswari College of Pharmacy,Anaikuttam-626 130(TN)India
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
The present study was aimed towards the formulation and invitro evaluation of rapidly disintegrating Sertraline hydrochloride, a new antidepressant as a model drug. Fast disintegrating tablets of sertraline hydrochloride was formulated using 5% and 10% concentration of superdisintegrants like Crospovidone, Croscarmellose sodium, Prgelatinized starch, low-substituted hydroxy propyl cellulose( L-HPC) and Sodium starch glycolate. A novel diluent (a combination of mannitol and silicified microcrystalline cellulose(SMCC) ) in the ratio 70:30 was used in the study. All the formulations were prepared by direct compression method (Rimek II minipress) using 9.5mm flat-faced punches. Prepared tablet were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time, wetting time, drug content and dissolution study. Disintegration time, wetting time and in vitro drug release were taken as the basis to optimize the best fast disintegrating formulation. Formulations containing crospovidone and croscarmellose sodium displayed shortest disintegration and wetting time and maximum dissolution compared to other disintegrants. Optimized formulations (S2and S4) were subjected to stability studies for thirty days which showed stability with regards to release pattern. Overall results suggests that a 10% disintegrant concentration is suitable for the preparation of sertraline hydrochloride fast disintegrating tablets and the tablets containing disintegrants Crospovidone (S2) and croscarmellose sodium (S4) are the best.


Cite this article:
Ganesan V , Lokesh Mangalmurti Chitrivekar. Formulation and In-vitro Evaluation of Fast disintegrating Tablets using Sertraline Hydrochloride as a model Drug. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 412-416.


Recomonded Articles:

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Uday Gaikwad, Milind Parle

DOI: Not Available         Access: Open Access Read More

Author(s): Mettu Srikanth Reddy, Mallikarjun Setty

DOI: Not Available         Access: Open Access Read More

Author(s): Saleem M.A., Sudhir S. Pange, Shaikh Ahnaf Umair, Vishal Kumar Singh

DOI: Not Available         Access: Open Access Read More

Author(s): M.A. Saleem, Raghavendra V. Kulkurni, Patil Noornadim G

DOI: Not Available         Access: Open Access Read More

Author(s): Priti Patel, Ashok Kumar P., Hemil Shah, Nikunj Patel, Pratik Kheni, Someshwara Rao B., Suresh V. Kulkarni, Babitha S.

DOI: Not Available         Access: Open Access Read More

Author(s): R. S. Adnaik, P. S. Gavarkar, S. K. Mohite, C, S Magdum

DOI: Not Available         Access: Open Access Read More

Author(s): Pavani M., D.P. Mastan Yadav, Manikanta Kumar A., K.S. Manjunath Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Dinesh S. Nandare, Satish K. Mandlik, Sachin K. Khiste, Yogesh D. Mohite

DOI: Not Available         Access: Open Access Read More

Author(s): Mahaveer Singh, Gautam Singhvi, SG Kaskhedikar, Love soni

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags