Author(s): D Nagavalli, ASK Sankar, K Anandakumar, T Vetrichelvan, M Balaji

Email(s): d_nagavalli@yahoo.co.in

DOI: Not Available

Address: D Nagavalli*, ASK Sankar, K Anandakumar, T Vetrichelvan, M Balaji
Dept. of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, T.N., India. 603319.
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
A simple, selective, rapid and precise RP-HPLC method for the estimation of Metaxalone in bulk material and in pharmaceutical formulation has been developed and validated. An isocratic elution at a flow rate of 1.0 ml/min was employed on a Phenomenax Luna C18 column (150 X 4.6 mm i.d., 5 m) at ambient temperature. The mobile phase consisted of Phosphate buffer: pH (5.0) Acetonitrile: Methanol in the ratio of (40:40:20). The UV detection wavelength was documented at 280 nm. The retention time Metaxalone was found to be 4.19 min. The method obeys Beer's Law in the concentration range of 20-100 mg/ml. The method was validated as per standard analytical procedures. The correlation co-efficient value was found to be 0.9997. The limit of detection and the limit of quantification were found to be 0.0.3205 mg/ml and 0.9712 mg/ml respectively. The amount of Metaxalone present in formulation was found to be 399.98 mg. The method was validated statistically and by recovery studies. Hence, the proposed method can be proficiently applied for the routine analysis of Metaxalone in bulk and in tablet formulation.


Cite this article:
D Nagavalli, ASK Sankar, K Anandakumar, T Vetrichelvan, M Balaji. Estimation of Metaxalone in Bulk and in Tablet Dosage Form by RP-HPLC. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 409-411.

Cite(Electronic):
D Nagavalli, ASK Sankar, K Anandakumar, T Vetrichelvan, M Balaji. Estimation of Metaxalone in Bulk and in Tablet Dosage Form by RP-HPLC. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 409-411.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2010-3-2-71


REFERENCES:

1.       Nirogi, R.V. Kandikere, V.N. Shukla, M. Mudigonda, K. Shrivastava, W. Datla, P.V. Quantification of Metaxalone in human plasma by Liquid chromatography coupled to tandem mass spectrometry.  Journal of Analytical Toxicology, Florida, (Vol-30), 4, 2006, 245-251.

2.       ICH, Q2A, Text on Validation of Analytical Procedures, International Conference on Harmonization,  Geneva,October 1991, 1-5.

3.       ICH, Q2B, Validation of Analytical Procedures: Methodology, International Conference on Harmonization, Geneva, November, 1996, 1-8.

4.       Kamboj, P.C., Pharmaceutical Analysis, 1st Edn., Vallabh.Publications, New Delhi, 2003, 1, 155.

5.       United States Pharmacopoeia. XXIII, 22nd Revision, United States of Pharmacopoeia Convention, Inc., U.S.A, 1995, 2132-2136.

6.       Gupta, S.C., Fundamentals of Statistics, 4th Edn., Himalaya publishing house,New Delhi , 1999


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Suha Alnaeb, Youssef Alahmad, Saleh Trefi

DOI: 10.5958/0974-360X.2019.01035.7         Access: Open Access Read More

Author(s): Dhara Parekh, Pankaj Kapupara, Ketan Shah

DOI: dharaparekh92@gmail.com         Access: Open Access Read More

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Author(s): R Deveswaran, S Bharath, BV Basavaraj, Sindhu Abraham, Sharon Furtado, V Madhavan

DOI:         Access: Open Access Read More

Author(s): Bahubali N. Patil, Vamshi Krishna Tippavajhala, Girish Pai K

DOI: 10.5958/0974-360X.2019.00140.9         Access: Open Access Read More

Author(s): Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A.

DOI: 10.5958/0974-360X.2020.00614.9         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Author(s): Prabhakar Panzade, Prashant K Puranik

DOI: Not Available         Access: Open Access Read More

Author(s): Khan MU, Ghafoor A, Ishaq MT, Hasan B, Salman A, Tengku MA, Zubaidi AL, Nodrin S, Atif AB, Ilyas MN

DOI: 10.5958/0974-360X.2018.00794.1         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags