MV Srikanth, GV Murali Mohan Babu, SA Sunil, N Sreenivasa Rao, K Praveen Kumar, KV Ramana Murthy
MV Srikanth1*, GV Murali Mohan Babu2, SA Sunil1, N Sreenivasa Rao1, K Praveen Kumar3 and KV Ramana Murthy1
1 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.
2 Unichem Laboratories Ltd, Pilerne Industrial estate, Bardez, Goa-403511, India.
3Hetero Drugs Limited, Hetero Corporate Industrial Estates, Hyderabad-500 082, India
Volume - 3,
Issue - 2,
Year - 2010
The purpose of this study was to formulate and evaluate the solid dispersions of bicalutamide, a non- steroidal anti androgen. The role of various water-soluble carriers was studied for dissolution enhancement of a poorly soluble model drug, bicalutamide, using solid dispersion technique. Diverse carriers viz, Povidone K 30, Poloxamer 407 and Gelucire 50/13 were investigated for this purpose. Solid dispersions with Povidone K 30 were prepared by solvent evaporation technique and the dispersions with Poloxamer 407 and Gelucire 50/13 were prepared by fusion process.The results showed that Gelucire 50/13 based solid dispersions exhibited higher dissolution rate than other dispersions. Dissolution studies showed a significant change in the dissolution profile of bicalutamide when dispersed in hydrophilic carriers at varying concentrations, but the maximum drug release was exhibited by the dispersion made with Gelucire 50/13 containing drug: Gelucire 50/13 1:1.The dispersions were characterized by X-ray diffraction. The diffractions exhibited in PXRD reflected the change in the crystalline structure of the bicalutamide in povidone based dispersion, but not in other carrier dispersions.
Cite this article:
MV Srikanth, GV Murali Mohan Babu, SA Sunil, N Sreenivasa Rao, K Praveen Kumar, KV Ramana Murthy. Studies on the Effect of Hydrophilic Carriers in the Dissolution Rate Enhancement of Poorly Soluble Drug, Bicalutamide. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 592-595.