Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Simultaneous Estimation of Metoprolol and Atorvastatin in Combined Dosage Form

Author(s): V Niraimathi, V Prema, Ajithadas Aruna, A Jerad Suresh

Email(s): vnm_anr@yahoo.co.in

DOI: Not Available

Address: V Niraimathi*, V Prema , Ajithadas Aruna and A Jerad Suresh
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010

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ABSTRACT:
Three novel, simple, sensitive, economical, accurate, rapid and precise spectrophotometric methods have been developed for the simultaneous estimation of Metoprolol and Atorvastatin in pharmaceutical oral solid dosage form. Method A involves solving of simultaneous equations based on measurement of absorbance at two wavelengths 223nm and 241nm, ?max of metoprolol and atorvastatin respectively. Method B involves estimation by Absorbance ratio method at 231 nm ( iso absorptive point ) and at 241 nm ( ?max of atorvastatin ). Method C involves AUC for the normal spectrum. All the methods utilize methanol as solvent. Beer’s law was obeyed in the concentration range of 5-90 µg/mL for both the drugs and the linearity was established. The results of analysis have been validated statistically and by recovery studies. The proposed methods can be successfully applied for the estimation of metoprolol and atorvastatin in combined dosage form.


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Cite this article:
V Niraimathi, V Prema , Ajithadas Aruna, A Jerad Suresh. Simultaneous Estimation of Metoprolol and Atorvastatin in Combined Dosage Form. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 586-588.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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