Author(s): Venkatalakshmi R, Sasikala C, SP Silambarasan

Email(s): rvenkatalakshmi@yahoo.co.in

DOI: Not Available

Address: Venkatalakshmi R*1, Sasikala C1 and SP Silambarasan2
1Shri Vishnu College of Pharmacy, Vishnupur, West Godavari, Bhimavaram – 534 202, Andhra Pradesh, India.
2Dep. of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, (T.N.), India- 603 319.
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
Loperamide hydrochloride 180 mg mouth dissolving tablet was prepared by using super disintegrants such as Sodium starch glycolate, Croscarmellose Sodium, Crospovidone at various concentration and Sucralose, aspartame used as sweetening agent. The excipients were used for this study was based on the compatibility studies. All the formulations were prepared by direct compression method. Among all the formulations Crospovidone at 10 mg/tablet gives 98 % drug release at 12th minute by UV method. It was considered as optimized batch. The optimized batch was passes all the evaluation parameters and stability studies .The final formulation were packed in blister package.


Cite this article:
Venkatalakshmi R, Sasikala C, SP Silambarasan. Formulation and Evaluation of Loperamide Hydrochloride Mouth Dissolving Tablet by Using Super Disintegrants. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 530-534.


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