Author(s): Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP, Baheti DR

Email(s): pareshk5569@gmail.com

DOI: Not Available

Address: Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP and Baheti DR
Dept. Of Pharmaceutics, MVPS’s College of Pharmacy, Shivaji nagar, Gangapur Road, Nashik-422002
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
The present study was based on direct-compressed matrix tablets consisting of a combination of Metformin HCl with the hydrophilic polymers HPMC K 100M and hydrophobic polymers Ethylcellulose 7cps. The resulting formulation produced monolithic tablets with optimum hardness, uniform thickness, consistent weight uniformity low friability, drug content. In vitro release studies were carried out in 0.1N HCl for first 2h and followed by phosphate buffer at 6.8 over a period of 12hrs using USP type II dissolution apparatus. Applying different kinetic models, the mechanism of drug release from formulations was found to be followed Higuchi model. The swelling and gelling properties of hydrophilic polymer matrix like HPMC form protective barrier to influx of water and efflux of drug solution along with ethylcellulose which controls diffusion of drug towards surface of matrices. Due to these properties the combination of hydrophilic HPMC K 100M and hydrophobic EC in matrix have better retarding property to give desire dissolution profile.


Cite this article:
Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP, Baheti DR. Design and Evaluation of Sustained Release Matrix Tablet of Metformin Hydrochloride. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 522-525.


Recomonded Articles:

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Sajid Ali, Maryam Shabbir, Nabeel Shahid

DOI: 10.5958/0974-360X.2015.00019.0         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Author(s): M.A. Saleem, Raghavendra V. Kulkurni, Patil Noornadim G

DOI: Not Available         Access: Open Access Read More

Author(s): Thulasi V. Menon, C.I. Sajeeth

DOI: Not Available         Access: Open Access Read More

Author(s): Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP, Baheti DR

DOI: Not Available         Access: Open Access Read More

Author(s): Gupta Khemchand, Singhvi I., Ashawat M.S., Gupta Santosh Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): B Srivastava, Uttam Singh Baghel, Pradeep Swarnkar and Shuchi Dave

DOI: Not Available         Access: Open Access Read More

Author(s): Pankaj P. Ostwal, Yogesh L. Jadhav, Mayur S. Jain, Sumit P. Jain

DOI: Not Available         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Author(s): Sushil J. Pawar, Santosh Y. Nandedkar, Rajendra D. Wagh, Tanvir Shaikh, Vaibhav Jagtap

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags