Author(s): Kalaivani M, Manju Jose Pulikottil, Nisha Mary BM, Sakthivel R, Rajasekaran A

Email(s): kala_samy2002@yahoo.com

DOI: Not Available

Address: Kalaivani M*, Manju Jose Pulikottil, Nisha Mary BM, Sakthivel R and Rajasekaran A
KMCH College of Pharmacy, Kalapatti Road, Coimbatore-641 048, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
Tetanus toxoids vaccine is widely used to prevent tetanus. As it has a short biological half-life, a long acting tetanus toxoids formulation is desirable to improve patient compliance. The chitosan microspheres were prepared by an emulsion polymerization method using glutaraldehyde as the crosslinking agent. All microspheres were spherical and smooth with the mean particle size in the range of 30–38 µm. Drug release from the chitosan microspheres displayed a biphasic pattern characterized by an initial fast release, followed by a slower release. The released amount was decreased with an increase in the glutaraldehyde concentration. The time required for complete degradation of microspheres was increased from 144 to 264 h when the glutaraldehyde concentration increased from 0.1 to 0.7 ml. Biodistribution studies indicated that the degree of uptake by the M-cells of the peyer’s patches in the gut was higher than that of the other organs. All these results demonstrated that tetanus toxoids loaded chitosan microspheres can be used for passive M-cell targeting.


Cite this article:
Kalaivani M, Manju Jose Pulikottil, Nisha Mary BM, Sakthivel R, Rajasekaran A. Preparation and Characterisation of Alginate Coated Chitosan Microspheres for Bacterial Vaccines. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 503-506.


Recomonded Articles:

Author(s): S. Shalini Devi, Y. Sreenivasulu, K.V. Bhaskar Rao

DOI: Not Available         Access: Open Access Read More

Author(s): Rakesh N Tirpude, Prashant K Puranik, Sunil B Jaiswal and Salim Shehzad

DOI: Not Available         Access: Open Access Read More

Author(s): Syed Zia ul Quasim, Mohd Irfan Ali, Syed Irfan, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Gaurav Tiwari, Ruchi Tiwari, Brijendra Srivastava, Awani K. Rai

DOI:         Access: Open Access Read More

Author(s): John I D’souza, Harinath N More

DOI:         Access: Open Access Read More

Author(s): A Saravanakumar, Sunita Minz, Madhulika Pradhan, Pavani Sure, Atul N Chandu, Umesh Mishra, K Kamalakannan, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): Amit Kumar Panigrahi, Mathrusri M. Annapurna, K. Himashankar

DOI: Not Available         Access: Open Access Read More

Author(s): Chetan M Patel, Manan A Patel, Nikhil P Patel, PH Prajapati, CN Patel

DOI: Not Available         Access: Open Access Read More

Author(s): Mali Snehal D., Khochage Swapna R., Nitalikar Manoj M., Magdum Chandrakant S

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed E. Abdel-Hamid, Leyla H. Sharaf , Oludotun A. Phillips, Elijah O. Kehinde

DOI: Not Available         Access: Open Access Read More

Author(s): Hemant R. Badwaik, Deepa Thakur, Kalyani Sakure, Tapan Kumar Giri, Kartik T. Nakhate, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Author(s): Senthil S.P, Chandrasekaran N, Vengadesh M, Ganesan V, Sudhamani T, Senthilkumar K.L

DOI:         Access: Open Access Read More

Author(s): Jayanudin, Moh. Fahrurrozi, Sang Kompiang Wirawan, Rochmadi

DOI: 10.5958/0974-360X.2018.00633.9         Access: Open Access Read More

Author(s): Rahul Krishnan P R, Sivakumar R

DOI: 10.5958/0974-360X.2019.00696.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags