Author(s): Sheetal Dhar, Varsha Pokharkar

Email(s): vbpokharkar@yahoo.co.in

DOI: Not Available

Address: Sheetal Dhar and Varsha Pokharkar*
Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, 411038, Pune, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
Of the various attempts to prolong the gastric residence time, use of mucoadhesive polymers is the most sought after. The main objective was to prolong the residence of metformin hydrochloride formulation in upper gastrointestinal tract. Herein we report a method for the preparation of mucoadhesive drug delivery system for metformin hydrochloride, a water soluble drug, using HPMC K4M, Carbopol 934P and Carbopol 971P as mucoadhesive and release controlling polymers. The selection of mucoadhesive polymer was done on the basis of water uptake, shear stress measurement and detachment force. The formulations were prepared by tablet compression method and were evaluated for water uptake, mucoadhesion, differential scanning calorimetry, in vitro and in vivo release. The water sorption studies of the formulation indicated a curvilinear relation for the drug: polymer ratio. The in vitro release studies revealed that the optimum combination of HPMC K4M and Carbopol 971P in the formulation leads to sustained release with a lower burst. The non invasive technique of gamma scintigraphy was explored which confirmed the exact position of the formulation within the gastrointestinal tract. Hence, it is concluded that the mucoadhesive formulation of metformin hydrochloride using mucoadhesive and release controlling polymers could sustain the drug release and remain in upper gastrointestinal tract so that the drug would be available in the dissolved form at the main site of its absorption.


Cite this article:
Sheetal Dhar, Varsha Pokharkar. Formulation Development of Mucoadhesive Matrix Tablet for Metformin Hydrochloride: In-Vitro and In-Vivo Evaluation. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 483-489.


Recomonded Articles:

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Author(s): J. Satyanarayana, A. Pavan Kumar, V. Sai Kishore, T.E. Gopala Krishna Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao U.S., Suganya M. Utharkar, C. Shanmuga Sundaram

DOI: 10.5958/0974-360X.2015.00307.8         Access: Open Access Read More

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Author(s): Alai M.S., Shinkar D.M., Saudagar R.B.

DOI: 10.5958/0974-360X.2017.00646.1         Access: Open Access Read More

Author(s): Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP, Baheti DR

DOI: Not Available         Access: Open Access Read More

Author(s): B Srivastava, Uttam Singh Baghel, Pradeep Swarnkar and Shuchi Dave

DOI: Not Available         Access: Open Access Read More

Author(s): Archana Kajale, B. V, Bakde, M. A. Channawar

DOI: Not Available         Access: Open Access Read More

Author(s): Lalit Singh, Arun Nanda, Bhupinder Singh, Saurabh Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): M Ali, Ezzat A Genady, Sarfaraz Ahmad, MS Alam, SA Khan, SAH Abdi, MS Harsoliya

DOI: Not Available         Access: Open Access Read More

Author(s): Kothapalli LP, Mare SG, Thomas AB, Nanda RK, Deshpande AD

DOI:         Access: Open Access Read More

Author(s): Tom Damien, Someshwara Rao B., Ashok Kumar P., Amith S. Yadav, Suresh V. Kuikarni

DOI:         Access: Open Access Read More

Author(s): Jalpa G. Patel, Sweta S. Solanki, Karan B. Patel, Manish P. Patel, Jayvadan K.Patel

DOI: Not Available         Access: Open Access Read More

Author(s): UK Patil, Ravish Sahu, SK Yadav

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags