PV Andhale, RS Jadhav, RD Bhalke, VD Tambe, MH Kolhe
PV Andhale2, RS Jadhav2, RD Bhalke1*, VD Tambe2 and MH Kolhe2
1Dept. of Pharmacognosy, Sanjivani College of Pharmaceutical Education and Research, Kopergaon-423603
2Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413 736), Tal- Rahata, Dist-Ahmednagar. (M.S.)
Volume - 3,
Issue - 2,
Year - 2010
Present study reports analgesic activity of petroleum ether, chloroform, methanolic and aqueous extract of leaves of Thuja orientalis. Hot plate and tail immersion methods were used for evaluation of central analgesic activity and acetic acid induced writhing model was used for evaluation of peripheral analgesic activity. Hot plate acetic acid induced writhing model was used for evaluation of central analgesic activity as well as peripheral analgesic activity. Results indicate that petroleum ether extract of leaves at 50 mg/kg, i.p. dose produced a significant increase in reaction time (P<0.05) in tail immersion method and increased in response latency period (P<0.05) in hot plate method, against standard drug pentazocin. Aqueous extract of leaves of Thuja orientalis significantly (P<0.05) attenuated the number of writhing when compared to standard drug paracetamol in acetic acid induced writhing model.
Cite this article:
PV Andhale, RS Jadhav, RD Bhalke, VD Tambe, MH Kolhe. Analgesic Activity of Thuja orientalis Leaves. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 435-437.