Author(s): Suhas Nalle, Rupali Sarpate, Mallikarjuna Setty, Patan Inayat, Anand Deshmuk

Email(s): suhasnalle@yahoo.com

DOI: Not Available

Address: Suhas Nalle *, Rupali Sarpate, Mallikarjuna Setty, Inayat Pathan and Anand Deshmukh
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425 107, Dist-Jalgaon, India.
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010


ABSTRACT:
Nateglinide, a novel anti-diabetic drug used for management of type II (noninsulin-dependent) diabetes mellitus (NIDDM) was formulated into matrix tablet using hydrophilic polymers such as HPMC, HPC, and Na CMC as release retardants. In present study, the hydrophilic matrixes prepared were containing a blend of one or more gel forming polymer and then the binary mixture was finally prepared having different concentrations. The concentration of nateglinide was kept constant and MCC was used as filler. The tablets were evaluated for hardness, friability, thickness, drug content, invitro release. In the present study, the effect of polymer concentration, binary polymer mixture and direct compression methods on drug release profiles was studied. It was observed that the type of polymer and its concentration influences the drug release from matrix tablets. Matrix tablets that contained a blend of Na CMC and cellulose ethers, successfully sustained the release of nateglinide for a period of 12 hrs. Nateglinide was predominantly released by non-fickian (anomalous) mechanism that is diffusion through the honeycomb network and polymer relaxation.


Cite this article:
Suhas Nalle , Rupali Sarpate, Mallikarjuna Setty, Patan Inayat, Anand Deshmuk. Controlled Release Nateglinide Tablets Using Na-CMC and HPC Hydrophilic Polymer. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 87-91.


Recomonded Articles:

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Saranya, Parthasarathy V, Hariprasad B, Shobha Rani H

DOI: 10.5958/0974-360X.2016.00233.X         Access: Open Access Read More

Author(s): Ankita Chatterjee, Jayanthi Abraham

DOI: 10.5958/0974-360X.2016.00125.6         Access: Open Access Read More

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags