Author(s): Bhupendra Shrestha, Hema Basnett, Sita Sharan Patel, Rashmi Karki, Shivani Agarwal, R Mazumder and B Stephenrathinaraj

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Address: 1Department of Pharmaceutical Chemistry, Himalayan Pharmacy Institute, Majhitar, E.Sikkim-737136. 2Dept. of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and AHS, Howrah, West Bengal-711316. 3Dept. of Pharmaceutical Analysis, Vaagdevi C

Published In:   Volume - 3,      Issue - 1,     Year - 2010

A simple, sensitive, accurate, reproducible and stability indicating RP-HPLC method was developed for the rapid analysis of Ciprofloxacin in tablet dosage form. The chromatographic separation was performed on a RP C18 (250 x 4.6 i.d) mm, 5µm, column. The mobile phase of the method consists of equal amount of acetonitrile and methanol along with 1% acetic acid in aqueous solution in the ratio of 8:8:84 v/v in the flow rate of 1.5 mL/min. The retention time for ciprofloxacin is found to be 7.7min when monitored at 280 nm. The detector response was linear in the concentration range of 200-700 µg/mL. The limit of detection and limit of quantification was 15.145 and 44.784 µg/mL respectively. The percentage assay of Ciprofloxacin was 99.92%. Correlation coefficient (r) of the regression equation is more than 0.999. The precision of the method was established by intra and inter day assay values which were less than 1%. None of the degraded products interfered with the Ciprofloxacin peak thus ensuring stability indicating nature of the method.

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