Author(s): Bhupendra Shrestha, Hema Basnett, Sita Sharan Patel, Rashmi Karki, Shivani Agarwal, R Mazumder and B Stephenrathinaraj

Email(s): Email ID Not Available

DOI: Not Available

Address: 1Department of Pharmaceutical Chemistry, Himalayan Pharmacy Institute, Majhitar, E.Sikkim-737136. 2Dept. of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and AHS, Howrah, West Bengal-711316. 3Dept. of Pharmaceutical Analysis, Vaagdevi C

Published In:   Volume - 3,      Issue - 1,     Year - 2010


ABSTRACT:
A simple, sensitive, accurate, reproducible and stability indicating RP-HPLC method was developed for the rapid analysis of Ciprofloxacin in tablet dosage form. The chromatographic separation was performed on a RP C18 (250 x 4.6 i.d) mm, 5µm, column. The mobile phase of the method consists of equal amount of acetonitrile and methanol along with 1% acetic acid in aqueous solution in the ratio of 8:8:84 v/v in the flow rate of 1.5 mL/min. The retention time for ciprofloxacin is found to be 7.7min when monitored at 280 nm. The detector response was linear in the concentration range of 200-700 µg/mL. The limit of detection and limit of quantification was 15.145 and 44.784 µg/mL respectively. The percentage assay of Ciprofloxacin was 99.92%. Correlation coefficient (r) of the regression equation is more than 0.999. The precision of the method was established by intra and inter day assay values which were less than 1%. None of the degraded products interfered with the Ciprofloxacin peak thus ensuring stability indicating nature of the method.


Cite this article:
Not Available

Cite(Electronic):
Not Available   Available on: https://rjptonline.org/AbstractView.aspx?PID=2010-3-1-42


Recomonded Articles:

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): R. P. Bhole, S. R. Jagtap, K. B. Chadar, Y. B. Zambare

DOI: 10.5958/0974-360X.2020.00189.4         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Vijaykumar T. Pawar, Shubhangi V. Pawar, Harinath N. More, Anita S. Kulkarni, Dinanath T. Gaikwad

DOI: 10.5958/0974-360X.2017.00724.7         Access: Open Access Read More

Author(s): Khan MU, Ghafoor A, Ishaq MT, Hasan B, Salman A, Tengku MA, Zubaidi AL, Nodrin S, Atif AB, Ilyas MN

DOI: 10.5958/0974-360X.2018.00794.1         Access: Open Access Read More

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Author(s): Aiyalu Rajasekaran, Thangadurai Beneeta, Krishnadas Meeradas, Joy Thomas Sajini, Sandeep Narayanan

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags