ABSTRACT:
Two simple, accurate, precise, rapid and economical methods have been developed for the simultaneous estimation of Nitazoxanide and Ofloxacin in combined tablet dosage form. First method is Vierodt’s method (Method A), where the wavelengths selected for quantitation were 347nm (?max of Nitazoxanide) and 295nm (?max of Ofloxacin). Second method is absorbance correction method (Method B), is based on correcting the absorbance of the component of interest from the total absorbance of the sample and the wavelengths used for estimation of Nitazoxanide and Ofloxacin were 380 nm. and 295 nm. Both the methods were validated statistically and recovery studies were carried out. Both drugs show linearity in the concentration range of 2 – 30 µg/ml. Linearity of Nitazoxanide and Ofloxacin were in the range of ± 20% of the test concentration. The proposed methods have been applied successfully to the analysis of the cited drugs in pharmaceutical formulations with good accuracy and precision. The methods herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.