Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Preparation, Physicochemical Characterization, Dissolution and Formulation Studies of Telmisartan Cyclodextrin Inclusion Complexes

Author(s): Rajesh Kane, Suresh Naik, Shrinivas Bumrela and Bhanudas Kuchekar

Email(s): Email ID Not Available

DOI: Not Available

Address: 1Sinhgad Institute of Pharmaceutical Sciences, Lonavala. Dist-Pune. Maharashtra, India. 410- 401 2MIT’s Maharashtra Institute of Pharmacy, Erandavane, Pune. Maharashtra, India.

Published In:   Volume - 3,      Issue - 1,     Year - 2010

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ABSTRACT:
The objective of this research was to prepare, characterize and to study dissolution properties of inclusion complexes of telmisartan (TLM), with β- cyclodextrin and hydroxypropyl- β- cyclodextrin and to study its effect on rate of dissolution. The phase solubility curve was classified as an AP type for both the CD’s, which indicated formation of inclusion complex of TLM in 1:2 stoichiometries with β-CD and HP-β-CD. The inclusion complexes in molar ratio of 1:2 were prepared by various methods such as kneading, co-evaporation and physical mixing. The molecular behavior of TLM in all samples were characterized by fourier- transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and powder x-ray diffraction studies. The result of studies showed inclusion of TLM molecule into cyclodextrin cavities. The highest improvement in in-vitro dissolution of TLM was observed in complex prepared with HPβ-CD using kneading method. Mean dissolution time (MDT) and similarity factor (f2) indicated significant difference between the release profile of TLM from complexes, physical mixture and pure TLM. The highest improvement in solubility and in-vitro drug release were observed in inclusion complex prepared with HPβ-CD by kneading method. Improvement in solubility and in-vitro drug release of Telmisartan were more with HPβ-CD as compared to β-CD


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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