Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Dissolution Enhancement of Clarithromycin by Formation of Surfactant Containing Microparticles

Author(s): MS Gambhire, VM Gambhire, K Maske

Email(s): makarandgambhire@yahoo.co.in

DOI: Not Available

Address: MS Gambhire*, VM Gambhire and K Maske
Sinhgad College of Pharmacy, Vadgaon (Bk), Pune 411041 (M.S.)
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010

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ABSTRACT:
The slow dissolution rate exhibited by poorly water-soluble drugs is a major challenge in the development process. Following oral administration, drugs with slow dissolution rates generally show erratic and incomplete absorption, which may lead to therapeutic failure. The aim of this study was to improve dissolution rate. Microparticles containing the model drug (clarithromycin) were produced by spray drying the drug in the presence of a surfactant. Poloxamer 407 was chosen as the surfactant to improve particle wetting and therefore the dissolution rate. The spray-dried particles were characterized and in vitro studies were carried out. The result obtained shows that dissolution rate of spray-dried clarithromycin and Poloxamer 407 particles were increased. Clarithromycin is water insoluble drug, after formulation of microparticles solubility is increased.


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Cite this article:
MS Gambhire, VM Gambhire, K Maske. Dissolution Enhancement of Clarithromycin by Formation of Surfactant Containing Microparticles. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 199-201.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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