Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Dissolution Enhancement of Clarithromycin by Formation of Surfactant Containing Microparticles

Author(s): MS Gambhire, VM Gambhire, K Maske

Email(s): makarandgambhire@yahoo.co.in

DOI: Not Available

Address: MS Gambhire*, VM Gambhire and K Maske
Sinhgad College of Pharmacy, Vadgaon (Bk), Pune 411041 (M.S.)
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010

 View HTML        View PDF

ABSTRACT:
The slow dissolution rate exhibited by poorly water-soluble drugs is a major challenge in the development process. Following oral administration, drugs with slow dissolution rates generally show erratic and incomplete absorption, which may lead to therapeutic failure. The aim of this study was to improve dissolution rate. Microparticles containing the model drug (clarithromycin) were produced by spray drying the drug in the presence of a surfactant. Poloxamer 407 was chosen as the surfactant to improve particle wetting and therefore the dissolution rate. The spray-dried particles were characterized and in vitro studies were carried out. The result obtained shows that dissolution rate of spray-dried clarithromycin and Poloxamer 407 particles were increased. Clarithromycin is water insoluble drug, after formulation of microparticles solubility is increased.


Keywords:

Cite this article:
MS Gambhire, VM Gambhire, K Maske. Dissolution Enhancement of Clarithromycin by Formation of Surfactant Containing Microparticles. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 199-201.


Recomonded Articles:

Screening Methods for Hepatoprotective Agents in Experimental Animals

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

A comparative, Bioequivalence study to evaluate the safety and pharmacokinetic profile of single dose Ivabradine 7.5mg Tablets in healthy, adult, human subjects under fasting condition.

Author(s): Amol K Choulwar, Ashish A. Mungantiwar, Meena Chintamaneni

DOI: Not Available         Access: Open Access Read More

Influence of Ginkgo Biloba (Egb) extracts in Apoptosis Index and Number of Neurons at Rattus Novergicus with Lead (Pb) Exposure

Author(s): Muhammad Hamdan, Noorhamdani AS, Masruroh Rahayu, Mohammmad Hasan Machfoed

DOI: 10.5958/0974-360X.2019.01020.5         Access: Open Access Read More

Local Anesthetics in Pediatric Dental Practice

Author(s): Trophimus Gnanabagyan Jayakaran, Vignesh R, Shankar P

DOI: 10.5958/0974-360X.2019.00700.5         Access: Open Access Read More

A Prospective Study on Drug Utilization Evaluation of Antibiotics for Surgical Prophylaxis

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Formulation Development and Characterization of Etodolac Loaded Transethosomes for Transdermal Delivery

Author(s): S. B. Gondkar, Neha R. Patil, R. B. Saudagar

DOI: 10.5958/0974-360X.2017.00541.8         Access: Open Access Read More

Formulation and Evaluation of Transdermal Drug Delivery Systems of Ivabradine Hydrochloride

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

A Prospective Study of Drug Utilization and Evaluation of Gastro Intestinal Agents

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Formulation and Characterization of Taste Masked Rapid Disintegrating Tablets of Trimetazidine HCl

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Approaches and Challenges of Protein and Peptide Drug Delivery Systems

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Chemo Preventive Activity of Triumfetta rhomboidea in 7, 12-Dimethylbenz (A) Anthracene Induced Breast Cancer in Sprague –Dawley Rat Model

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Vanilla- Natural Vs Artificial: A Review

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Carriers used for the development of solid dispersion for poorly water-soluble drugs

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Preparation and Evaluation of Ocular Inserts For Controlled Delivery of Ciprofloxacin Hydrochloride

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Taste Masking: A Review

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Effect of Chemical Enhancers on in-vitro Permeation of Losartan Potassium

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Topical Gels: A Review

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available         Access: Open Access Read More

Development and Evaluation of Mucoadhesive Buccal Patches of Nifedipine

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Halitosis: Classification, Causes, and diagnostic as well as Treatment Approach – A Review

Author(s): Mahadeva Rao U.S., Suganya M. Utharkar, C. Shanmuga Sundaram

DOI: 10.5958/0974-360X.2015.00307.8         Access: Open Access Read More

Development and Evaluation of Sustained Release Matrix Tablets Using Natural Polymer as Release Modifier

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Design, Synthesis, Characterization and Antioxidant activity of Novel Benzothiazole and Coumarin based 6-(3, 5-dimethylpyrazol-1-yl) pyridazin-3-one Derivatives
The Thermodynamic parameters of Chlorpromazine hydrochloride partitioning into Dimyrstoylphosphatidylcholine liposomes
The regulatory role of Neurotransmitters in Orexin B induced Nucleus Accumbens dependent alcohol ingestion in Wistar albino rats
Compounding practice in a developing Country: A Case study of divided Powder in Indonesia
Estimation of Anti-Diabetic property of Holarrhena pubescens by In Vitro method using L6 rat Skeletal Muscle Cell Lines
Synthesis, Spectral Characterization and Anticancer activity of Novel Pyrimidine Derivatives
Colon Specific Drug Delivery Systems – Different Systems and Approaches: A Review
Role of Dietary Supplements in Sports Performance
Bora Rice: Natural polysaccharide polymer for drug delivery
An outline on Curcumin: Its pro-liposome and Liposome Formulations
An Insight on pain modulation with Gender and Obesity: A Systematic Review
CNS and COVID-19: Neurological symptoms of Hospitalized Patients with Coronavirus in Iraq: a surveying case sequences study
Comparative Studies of the Amino acids profile Persicaria hydropiper L. Delarbre and Persicaria minor Hunds., growing in the Voronezh region (Russia)
Association of Leptin in Diabetes Mellitus and Obesity
Development and Evaluation of topical Emulgel of Aspirin using different Polymeric Bases
Formulation and Evaluation of Microemulsion containing Anti-Hypertensive Drug
Studying the prevalence of genital Chlamydia trachomatis IgG serum antibodies and associated risk factors in heterosexual men attending Tishreen University Hospital, Syria
Effect of Encapsulated Lactobacillus rhamnosus GG in Antibiotic associated diarrhea in Albino Wistar rat model
Pharmacognostic Evaluation and Standardization of the leaves of Mimosa pudica, leaves of Murraya koenigii and root of Asparagus racemosus
Quantitative Analysis of Combined Analgetic Tablets

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 7291
Yesterday: 10921
Total: 5322062