Akbari BV, Dholakiya RB, Shiyani BG, Lodhiya DJ
Akbari B. V.*, Dholakiya R. B., Shiyani B. G. and Lodhiya D. J.
Dept. of Pharmaceutics, Shree Dhanvantary Pharmacy College and Shree Dhanvantary Pharmaceutical Analysis and Research Center, Nr. Railway Station, Kudsad road, Kim (E),Surat-394110,Gujarat, India
Volume - 3,
Issue - 1,
Year - 2010
The present investigation an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance, by developing sustained release matrix tablet of baclofen. Sustained release matrix tablet of baclofen, were developed by using different drug: polymer ratio. HPMC K4M, HPMC K100M and Xanthan gum was used as matrix former. All lubricated formulations were compressed using 9mm punch. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution using basket method, and swelling index. All the formulation showed compliance with pharmacopoeias standards. Among the different formulation, B7 showed sustained release of drug for 12 hours with 97.46 % release. The selected formulation (B7) was subjected to stability studies for one month at room temperature, 2-8 0 c and 400c with RH 75±5%, and showed stability with respect to release pattern. The kinetic model fitted showed that the release of drug follows zero order kinetics (R2=0.9914). korsemeyer- peppas equation gave value of n=0.78 which was close to one, indicating that drug was released by non-fickian release mechanism. Thus, combination of HPMC K4M and K100M were found to be effective in retarding the release of baclofen.
Cite this article:
Akbari BV, Dholakiya RB, Shiyani BG, Lodhiya DJ. Design and Study on Effect of Hydrophilic Polymers on Release Rate of Baclofen SR Matrix Tablet. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 193-198.