ABSTRACT:
Benzoin was reacted with aminomethamine in ethanol to yield 2-amino-4,5-diphenylimidazole, which on further reaction with dichloromethane in presence of ethanolic potassium hydroxide yielded 2-(chloromethylamino)-4,5-diphenylimidazole. The 2-(chlormethylamino)-4,5-diphenylimdazole was reacted with piperazine and its derivatives, which yielded 2-(piperazinomethylamino)-4,5-diphenylimiazole and its respective derivatives. All the compounds were characterized on the basis of IR and 1HNMR spectral data were screened for antimicrobial activity.
Cite this article:
SP Wate, AN Ingale, PS Tarte. Synthesis and Antimicrobial Evaluation of Some 2- (Piperazinomethylamino) Imidazole Derivatives. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 154-156.
Cite(Electronic):
SP Wate, AN Ingale, PS Tarte. Synthesis and Antimicrobial Evaluation of Some 2- (Piperazinomethylamino) Imidazole Derivatives. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 154-156. Available on: https://rjptonline.org/AbstractView.aspx?PID=2010-3-1-25