Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Synthesis and Antimicrobial Evaluation of Some 2- (Piperazinomethylamino) Imidazole Derivatives

Author(s): SP Wate, AN Ingale, PS Tarte

Email(s): pawantarte@rediffmail.com

DOI: Not Available

Address: SP Wate, AN Ingale and PS Tarte*
Sharad Pawar College of Pharmacy, Wandongari, Hingana Road, Nagpur-441110 (M. S.)
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010

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ABSTRACT:
Benzoin was reacted with aminomethamine in ethanol to yield 2-amino-4,5-diphenylimidazole, which on further reaction with dichloromethane in presence of ethanolic potassium hydroxide yielded 2-(chloromethylamino)-4,5-diphenylimidazole. The 2-(chlormethylamino)-4,5-diphenylimdazole was reacted with piperazine and its derivatives, which yielded 2-(piperazinomethylamino)-4,5-diphenylimiazole and its respective derivatives. All the compounds were characterized on the basis of IR and 1HNMR spectral data were screened for antimicrobial activity.


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Cite this article:
SP Wate, AN Ingale, PS Tarte. Synthesis and Antimicrobial Evaluation of Some 2- (Piperazinomethylamino) Imidazole Derivatives. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 154-156.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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