Sinha PK, Jeswani RM, Topgi KS, Damle MC
Sinha PK, Jeswani RM, Topgi KS and Damle MC
A.I.S.S.M.S College of Pharmacy, Near RTO, Kennedy Road, Pune, Maharashtra-411001, India
Volume - 3,
Issue - 1,
Year - 2010
A stability indicating isocratic RP-LC method has been developed for the quantitative determination of Potassium Clavulanate in presence of its hydrolytic degraded products. Chromatographic separation was achieved on a C18 Nucleosil column with mobile phase consisting of 0.7% sodium dihydrogen phosphate and methanol in the ratio of 90: 10 v/v; retention time of the drug was 4.2±0.05 min, quantification was carried out at 230 nm with flow rate of 1 mL min-1. In the developed LC method the resolution between potassium Clavulanate and products of degradation was found to be greater than 2 with r2 value greater than 0.997.
Cite this article:
Sinha PK, Jeswani RM, Topgi KS, Damle MC. Stability Indicating RP-HPLC Method for Determination of Potassium Clavulanate in the presence of its Degradation Products. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 141-145.