Author(s): Sinha PK, Jeswani RM, Topgi KS, Damle MC

Email(s): mcdamle@rediffmail.com

DOI: Not Available

Address: Sinha PK, Jeswani RM, Topgi KS and Damle MC
A.I.S.S.M.S College of Pharmacy, Near RTO, Kennedy Road, Pune, Maharashtra-411001, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010


ABSTRACT:
A stability indicating isocratic RP-LC method has been developed for the quantitative determination of Potassium Clavulanate in presence of its hydrolytic degraded products. Chromatographic separation was achieved on a C18 Nucleosil column with mobile phase consisting of 0.7% sodium dihydrogen phosphate and methanol in the ratio of 90: 10 v/v; retention time of the drug was 4.2±0.05 min, quantification was carried out at 230 nm with flow rate of 1 mL min-1. In the developed LC method the resolution between potassium Clavulanate and products of degradation was found to be greater than 2 with r2 value greater than 0.997.


Cite this article:
Sinha PK, Jeswani RM, Topgi KS, Damle MC. Stability Indicating RP-HPLC Method for Determination of Potassium Clavulanate in the presence of its Degradation Products. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 141-145.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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