Author(s): B Srivastava, Uttam Singh Baghel, Pradeep Swarnkar and Shuchi Dave

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Address: 1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-203025 Rajasthan, India. 2Department of Pharmacognosy, VNS College of Pharmacy, Bhopal (M.P.), India.

Published In:   Volume - 3,      Issue - 1,     Year - 2010


ABSTRACT:
Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of two-component drug mixture of metformin hydrochloride and glibenclamide in bulk and combined tablet dosage form have been developed. The first method employs formation and solving of simultaneous equations using 237.0 and 229.2 nm as two analytical wavelengths. The second method is absorption ratio method, which uses 237.0 and 225.0 nm as two analytical wavelengths. Both methods were statistically validated according to International Conference on Harmonization and recovery studies confirmed the accuracy of the proposed method.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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