Author(s): Shradhanjali M Singh, Kirti S Topagi, Mrinalini C Damle

Email(s): mcdamle@rediffmail.com

DOI: Not Available

Address: Shradhanjali M Singh, Kirti S Topagi, and Mrinalini C Damle*
Dep. of Pharmaceutical Chemistry, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune – 411001
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
A simple, accurate and precise high performance thin layer chromatographic method has been developed for the estimation of Valsartan and Nebivolol hydrochloride simultaneously from a tablet dosage form. The method employed silica gel 60 F254 precoated plates as stationary phase and a mixture of Ethyl acetate: Methanol: Ammonia (6.5:2.5:0.5 %v/v/v) as mobile phase. Densitometric scanning was performed at 280 nm using Camag TLC scanner 3. Beer’s law was obeyed in the concentration range of 800ng/spot-2400ng/spot for Nebivolol hydrochloride and 200ng/spot-1000ng/spot for Valsartan. The Retention factors for Nebivolol hydrochloride is 0.75 ± 0.04 and for Valsartan is 0.27 ± 0.01. The method was validated as per ICH Guidelines, proving its utility in estimation of Valsartan and Nebivolol hydrochloride in combined dosage form.


Cite this article:
Shradhanjali M Singh, Kirti S Topagi, Mrinalini C Damle. A Validated High Performance Thin Layer Chromatographic Method for Simultaneous Estimation of Nebivolol Hydrochloride and Valsartan in Pharmaceutical Dosage Form. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 746-748.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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