Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Simultaneous Estimation of Montelukast Sodium and Levocetirizine Hydrochloride from Tablet Dosage Form

Author(s): ASK Sankar, GN Baskar, D Nagavalli, K Anandakumar, T Vetrichelvan

Email(s): gnbaskar.mpharmanalyst@gmail.com

DOI: Not Available

Address: ASK Sankar, GN Baskar*, D Nagavalli, K Anandakumar and T Vetrichelvan
Adhiparasakthi College of pharmacy, Melmaruvathur-603 319, Tamilnadu.
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009

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ABSTRACT:
Three simple, accurate, economical and reproducible UV-Spectrophotometric methods for simultaneous estimation of Montelukast sodium (MK) and Levocetirizine hydrochloride (LC) from combined tablet dosage form have been developed and validated. First method uses absorbance correction principle using 287 and 232 nm, in which at 287nm LC has no absorbance. Second method uses multi wavelength, the wavelengths selected for estimation of MK were 232.2 and 229 nm where LC shows same absorbance. A third wavelength, 232 nm was selected for estimation of LC by applying absorbance correction principle. Third method was developed making use of first order derivative spectrophotometry 231.1 nm (Zero crossing point for LC) is utilized for estimation of MK and 216.5 nm (zero crossing point for MK) for estimation of LC.


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Cite this article:
ASK Sankar, GN Baskar, D Nagavalli, K Anandakumar, T Vetrichelvan. Simultaneous Estimation of Montelukast Sodium and Levocetirizine Hydrochloride from Tablet Dosage Form. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 743-745.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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