ABSTRACT:
A simple, precise and economical procedure for the simultaneous estimation of Valsartan (VAL) and Hydrochlorothiazide (HCT) in tablet formulation have been developed. VAL is a antihypertensive drug belonging to the family of angiotensin II receptor antagonists and HCT is one of the oldest thiazide diuretics. The oral administration of VAL with HCT has been found to be more effective than either drug alone in the treatment of hypertension in patients whose blood pressure is not adequately controlled by monotherapy. The present method involves the solving of simultaneous equations (Vierodt’s method).VAL has absorbance maxima at 250nm in methanol and HCT has absorbance maxima at 271nm in methanol. Both these drugs obey Beer’s law in the concentration range employed for the present method. The result of analysis has been validated statistically by recovery studies. The slope and intercept for VAL were 0.0265 and -0.003 and for HCT were 0.0571 and -0.0214 respectively as determined by the method of least squares. The results were found satisfactory and reproducible. The method was applied successfully for the estimation of VAL and HCT simultaneously in tablet dosage form without the interference of common excipients.