Author(s): Lata Kothapalli, Shivaji Mare, Veeren Dewoolkar, Anupam Banerjee, Asha Thomas, RK Nanda, AD Deshpande

Email(s): lpkothapallidy@yahoo.co.in

DOI: Not Available

Address: Lata Kothapalli*, Shivaji Mare, Veeren Dewoolkar, Anupam Banerjee, Asha Thomas, RK Nanda and AD Deshpande
Department of Pharmaceutical Chemistry, Pad. Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, Maharashtra, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
The proposed method is a simple, accurate, precise, specific and rapid method for the simultaneous estimation of Metformin hydrochloride and Fenofibrate in bulk and synthetic mixture using C18 column (Kromosil, 4.6mm x 25 cm, 5µm) with Acetonitrile: 0.02 M Ammonium acetate buffer (80: 20 v/v) as a mobile phase, at a flow rate of 1.0 ml/min and detection was done at 249.0 nm. The retention time for metformin hydrochloride and fenofibrate was found to be 2.63+ 0.011and 9.26+ 0.017 min. respectively. Linearity of metformin hydrochloride and fenofibrate were found in the range of 5–50 µg/ml and 0.8-8.0 µg/ml respectively. The percentage assay of metformin hydrochloride and fenofibrate was found between 98% to 102 %.The statistical parameters were found satisfactory.


Cite this article:
Lata Kothapalli, Shivaji Mare, Veeren Dewoolkar, Anupam Banerjee, Asha Thomas, RK Nanda, AD Deshpande. Simultaneous RP-HPLC Method for Estimation of Metformin Hydrochloride and Fenofibrate in Synthetic Mixture. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 694-697.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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