ABSTRACT:
The oral cavity has long been a site for mucosal and transmucosal delivery of drugs via Buccal route. However, as Buccal delivery, because of its undeniable advantages, has become popular for systemic drug delivery and prolonged well controlled release has been identified as beneficial, especially for chronic diseases. The buccal mucosa offers an alternative route to conventional, parenteral administration. It associated with buccal drug delivery have rendered this route of administration useful for a variety of drugs. The strategies to overcome the main obstacles that drugs meet when administered via the buccal route include the employment of new materials that, possibly, combine mucoadhesive, enzyme inhibitory and penetration enhancer properties. Buccal mucosa offers innovative drug delivery systems which, besides improving patient compliance, favor a more intimate contact of the drug with the rapid buccal absorption in mucosa. Developing a dosage form with the optimum pharmacokinetics is a promising area for continued research. With the right dosage form design, local environment of the mucosa can be controlled and manipulated in order to optimize the rate of drug dissolution and permeation. Further, these dosage forms are self administrable, cheap and have superior patient compliance.