Author(s): R Xavier Arulappa, M Sundarapandian, S Venkataraman, M Boopathi, Manish Kauraw

Email(s): xavilatha@yahoo.co.in

DOI: Not Available

Address: R Xavier Arulappa1*, M Sundarapandian2, S Venkataraman1, M Boopathi2 and Manish Kauraw1
1Department of Pharmaceutical Chemistry, 2Department of Pharmaceutical Analysis, K.M.College of Pharmacy, Uthangudi, Madurai -625 107. (TN). India.
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
A simple, rapid, economical and sensitive visible spectrophotometric method for the estimation of Quetiapine fumarate has been developed based on the formation of ion-pair of Quetiapine fumarate with dye bromocresol green in acidic medium, which was extracted into chloroform. It has absorption maxima at 415nm. Beer’s law limit was found to be 5-25mcg/ml. The molar absorptivity was found to be 4.5x104(mole-1cm-1) and sandell’s sensitivity was 0.01949 (µg/cm2/0.001 absorbance unit). The correlation coefficient (r) was found to be 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.29 and 0.88 mcg/ml respectively of Quetiapine fumarate. The result of estimation in marketed formulations were found to be 97.44±0.3286 and 96.68±0.07854. The proposed method was applied successfully for the determination of Quetiapine fumarate in tablets with average recovery of 98.83±0.2738 and 98.98±0.3535. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.


Cite this article:
R Xavier Arulappa, M Sundarapandian, S Venkataraman, M Boopathi, Manish Kauraw. Spectrophotometric Determination of Quetiapine Fumarate in Bulk and Dosage Form. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 880-881.


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DOI: 10.5958/0974-360X 

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