A new simple, sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Metformin hydrochloride in bulk and dosage form. Metformin hydrochloride was shown maximum absorbance at 232 nm with apparent molar absorptivity of 1.0781×10 4l/mol.cm. Beer’s law was obeyed in the concentration range of 10 to 50 ug/ml. Results of analysis were validated statistically and by recovery studies. The developed method was found to be sensitive, accurate, precise and reproducible and can be used for the routine quality control analysis of metformin hydrochloride.
Cite this article:
PM Patil, MA Phanse, VL Gaikwad, PD Chaudhari. Direct Spectrophotometeric Determination of Metformin Hydrochloride in Pure Form and in Pharmaceutical Formulations. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 874-875.