Author(s): Sudharshan SJ, Chinmaya A, Valleesha NC, Prashith Kekuda TR, Rajeshwara AN, Syed Murthuza

Email(s): prashith_kekuda@rediffmail.com

DOI: Not Available

Address: Sudharshan SJ1, Chinmaya A1, Valleesha NC1, Prashith Kekuda TR2*, Rajeshwara AN1 and Syed Murthuza3
1Dept. of Studies and Research in Biochemistry, Jnanasahyadri, Shankaraghatta-577451, Karnataka
2 Dept. of Microbiology, S.R.N.M.N College of Applied Sciences, NES Campus, Balraj Urs Road, Shivamogga-577201, Karnataka
3 Dept. of Studies and Research in Biochemistry, Shivagangothri, Tholhunse, Davangere-577002, Karnataka
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
Drypetes roxburghii Wall also called Putranjiva roxburghii Wall is a deciduous, evergreen tree and is used in cold, fever, rheumatism and inflammation. The aim of the present study was to evaluate the analgesic and CNS depressant property of methanol extract of seeds of Drypetes roxburghii Wall in mouse model. The analgesic activity of methanol extract was evaluated by Tail flick method. CNS depressant activity was determined using digital Actophotometer. The preliminary phytochemical analysis of methanol extract showed the presence of phenols, alkaloid, saponin, steroids, flavonoids, and glycosides while terpenoids and tannin were not detected. In analgesic activity, the reaction time increased significantly for the extract and standard groups when compared to the predrug treatment. The locomotor activity count in the extract and standard drug treated group was significantly reduced when compared to control group. The analgesic and CNS depressant activity of extract was found to be more than that of the standard drug. Further studies are needed to isolate the active constituents responsible for the observed effect and to reveal the possible mechanisms of action responsible for the analgesic and CNS activity.


Cite this article:
Sudharshan SJ, Chinmaya A, Valleesha NC, Prashith Kekuda TR, Rajeshwara AN, Syed Murthuza. Central Nervous System Depressant and Analgesic Activity of Methanolic Extract of Drypetes roxburghii Wall in Experimental Animal Model. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 854-857.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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