Author(s): S. Sudarshan, S. Sangeeta, NR Sheth, P. Roshan, YV Ushir, R. Gendle

Email(s): sudarshansingh83@gmail.com

DOI: Not Available

Address: S. Sudarshan*1, S. Sangeeta2, NR Sheth3, P. Roshan4, YV Ushir5 and R. Gendle6
1Dept. of Pharmaceutics, Shree H. N. Shukla Institute of Pharmaceutical Education and Research, Rajkot, (Gujarat.)
2Dept. of Pharmaceutical chemistry, C.P.S. Mahuda college of Pharmaceutical sciences, Bhermpur, (Orissa)
3Dept. of Pharmaceutical sciences, Saurasrta University, Rajkot, (Gujarat.), India
4Department of Pharmacognosy, Shree Leuva Patel Trust Pharmacy Mahila College, Amreli, (Gujarat.), India
5Dept. of Pharmacognosy, Shree H. N. Shukla Institute of Pharmaceutical Education and Research, Rajkot, (Gujarat)
6Dept. of Pharmaceutics, Institute of Pharmacy, RITEE, Raipur (Chhattisgarh) India.
Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
Ulcerative colitis is a disease of the intestine, explicitly the large intestine or colon that includes characteristic ulcers, or open sores, in the colon. For eradication of Ulcerative colitis, there are various methods among that delivery of drug to colon is one of them. Colon specific delivery can achieve by using polymer, which will release the drug at specific pH, or by enzyme depended system, which will break the bond between drugs and polymer. Present study was slanting to explore the utility of coating technology for colonic targeting of single unit tablet systems. Mesalamine USP Tablets were prepared using synthetic polymer as binders and methoxy polymer as release retardant. Different polymer such as Eudragit E100 and S100 used to get desired release of drug to colon for specific time. Core tablet were coated in singular percentage as 5%, 7.5% and 10%. Similarly core tablet were coated using triple coating using release retardant. The coated tablets were tested in-vitro for their suitability as colon specific drug delivery systems in different pH 1.2, 6.0 and 7.2. Drug release was delayed as on going on increasing the concentration of coating polymer. Triplicate coating gave 0.61% at pH 1.2, 0.49% at pH 6.0 and 87.28% at pH 7.2 from 75 mg tablet. Drug content was determined by UPLC and it was found 98.33% of drug was present in a tablet. The statistical analysis of the parameters of dissolution data obtained before and after storage for 3 month at 25ºC/60%RH and 40ºC/75%RH as per ICH guidelines showed no significant changes indicating the two dissolution profile were similar.


Cite this article:
S. Sudarshan, S. Sangeeta, NR Sheth, P. Roshan, YV Ushir, R. Gendle. Colon Specific Drug Delivery System of Mesalamine for Eradication of Ulcerative Colitis. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 819-823.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


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