Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Formulation and Evaluation of Floating Drug Delivery System of Cefpodoxime Proxetil

Author(s): Pathan DN, Shaikh NH, Thube RT, Bhise KS, Polshettiwar SA

Email(s): dilnawazpathan@gmail.com

DOI: Not Available

Address: Pathan DN1*, Shaikh NH1, Thube RT1, Bhise KS1 and Polshettiwar SA2
1Allana College of Pharmacy, Azam Campus, Camp, Pune, India.411001.
2MAEER’S Maharashtra Institute of Pharmacy, Kothrud, Pune, 411038
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2009

 View HTML        View PDF

ABSTRACT:
The objective of the present study was to develop floating drug delivery system of Cefpodoxime proxetil to increase its residence time in stomach as high solubility, chemical and enzymatic stability and absorption profile was observed in acidic pH value. The floating tablets of Cefpodoxime proxetil were prepared by direct compression method using sodium bicarbonate as floating agent and HPMC as rate retarding polymer. A 32 full factorial design was constructed to study the effect of the amount of HPMC and sodium bicarbonate on the drug release profile from the formulations. The formulations were evaluated for floating lag time, floating duration time and in vitro drug release studies. The optimized formulation showed sufficiently sustained drug release and remained buoyant on the surface of medium for more than 10 hours. It was observed that the increase of floating agent concentration displayed a common phenomenon that the drug release rate and extent were increased in all cases. As the concentration of HPMC increases in the formulation the release rate was found to be decreased. Accelerated stability studies were performed as per ICH guidelines at temperature of 40 ? 2 ºC and humidity 75 ? 5 %RH for a period of 3 months. The results indicated that these formulations remained stable. It can be concluded that floating drug delivery system of Cefpodoxime proxetil can be successfully formulated as an approach to increase gastric residence time and thereby improve its bioavailability.


Keywords:

Cite this article:
Pathan DN, Shaikh NH, Thube RT, Bhise KS, Polshettiwar SA. Formulation and Evaluation of Floating Drug Delivery System of Cefpodoxime Proxetil. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 812-815.


Recomonded Articles:

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Design and Characterization of Valsartan Co-Crystals to Improve its Aqueous Solubility and Dissolution Behavior

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

A comparative, Bioequivalence study to evaluate the safety and pharmacokinetic profile of single dose Ivabradine 7.5mg Tablets in healthy, adult, human subjects under fasting condition.

Author(s): Amol K Choulwar, Ashish A. Mungantiwar, Meena Chintamaneni

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Fast Melt-Away Wafers Using Selected Polymers

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Irbesartan nanosuspension for Dissolution Enhancement

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Curcumin and its Bioavailability Study

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Formulation and Evaluation of Extended Release Matrix Formulation of Metoprolol Succinate

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Floating Matrix Tablets of Labetalol Hydrochloride.

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Matrix Tablets of Pregabalin

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Transdermal Drug Delivery Systems of Ivabradine Hydrochloride

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Diclofenac gel

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Preparation and Characterization of Lercanidipine Hydrochloride Inclusion complex with β-cyclodextrin and effect of Complexation on Solubility and Dissolution

Author(s): Farhatjahan I. Shaikh, Meenakshi B. Patel, Naazneen I. Surti, Vandana B. Patel

DOI: 10.5958/0974-360X.2017.00189.5         Access: Open Access Read More

Formulation, Characterization and In-vitro Evaluation of Abacavir Sulphate Loaded Microspheres

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

In-Vitro and In-Vivo Correlation of Marketed Formulation of Nimesulide

Author(s): Kuldeep Malodia, Sunil Kumar, Pankaj Rakha, SK Singh, DN Mishra

DOI: Not Available         Access: Open Access Read More

A Review on Transbuccal Drug Delivery System and its Commercially Available Products

Author(s): M. Sunitha Reddy, Ch. Surekha, G. Anusha, S. Mallikarjun Reddy, K. Manasa, G. Sowmya

DOI: Not Available         Access: Open Access Read More

Carriers used for the development of solid dispersion for poorly water-soluble drugs

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Formulation and in vitro evaluation of gastroretentive drug delivery systems of amoxicillin trihydrate

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Development and Evaluation of Mucoadhesive Buccal Patches of Nifedipine

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Floating Drug Delivery System Using Losartan

Author(s): Gupalli Laxmi Narasimha, Dappu Jairam, Akkenapally Krishna, Mohammed Rehan Qureshi

DOI: 10.5958/0974-360X.2015.00025.6         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Microcapsules of Glimepiride

Author(s): J. Satyanarayana, A. Pavan Kumar, V. Sai Kishore, T.E. Gopala Krishna Murthy

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

Quick Links

Latest Issues

Popular Articles


Recent Articles



Antidepressant effect of Nigella sativa in stress-induced depression
Method Development and Validation for Simultaneous Estimation of Glimepiride and Simvastatin by using Reversed Phase High-performance Liquid Chromatography
Effect of Resveratrol Pretreatment on Intestinal Transport and Oral Bioavailability of Carvedilol in Rats by P-gp Inhibition
Correlation of Anti-oxidant, Anti-angiogenic, and Cytotoxic activity of Tanacetum parthenium compared with Amlodipine using Chorioallantoic membrane Assay
Factors Associated with Neonatal Healthcare-Associated Infections (HAIs) in India: A Protocol for Systematic Review and Meta-analysis
Separation of Carvedilol Enantiomers using HPLC by two Different Methods: Mobile Phase Chiral Additive and Chiral Stationary Phase
Formulation, Characterization and Ex vivo Evaluation of Epinephrine Transdermal Patches
Formulation and Evaluation of Herbal Lipsticks
Phytochemical analysis, Total Flavonoid, Phenolic contents and Antioxidant activity of extracts from the Leaves of Rhododendron arboreum
Diosmin anti-tumour efficacious against Hepatocellular Carcinoma
Curcumin and its Analogue Targeting β-Catenin and GSK-3β in Wnt Signaling Pathways: In Vitro and In Silico Study
Efficacy of Hand rubbing with alcohol based solution versus standard hand washing with soap and water in a Tertiary care Hospital in The North Iran
Assessment and Comparison of Pharmaceutical Equivalence of Amlodipine Besylate Tablets Available in Syria under Biowaiver Conditions
A New Spectrophotometric Method for the Micro Determination of Clopin-A with Bromo Cresol Green and its Application to Evaluate the Assay of the Drug
The Influence of Epigallocatechin Gallate on the Nuclear Factor Associated T Cell-1 and Sclerostin Expression in Wistar Rats (Rattus novergicus) during the Orthodontic Tooth Movement
Synthesis, Structural and Biological Studies of Some Metal Complexes derived from Tridentate Pyrazole-based Ligand
Genome-wide Identification and Annotation of metabolite producing Gene Clusters in Rice Genome
Development and Characterization of Mesalamine Microsphere for Colon Specific Drug Delivery
Pharmacognostic and Preliminary Phytochemical Investigation of Exacum bicolor Roxb
Formulation and Development of Sustained Release Pellets of Nifedipine by Fluidized Bed Processor

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 16865
Yesterday: 18827
Total: 1161352