Azithromycin Recrystallized Agglomerates with Hydrophilic Polymers and Surfactant by Neutralization Technique

AV Yadav; VB Yadav

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

Submit Article

Azithromycin Recrystallized Agglomerates with Hydrophilic Polymers and Surfactant by Neutralization Technique

Author(s): AV Yadav, VB Yadav

Email(s): venkat_yadav3@rediffmail.com

DOI: Not Available

Address: AV Yadav1 and VB Yadav2
1 Goa College of Pharmacy, Panaji.
2 Govt.College of Pharmacy, Vidyanagar, Karad, Dist-Satara (MS), India
*Corresponding Author

Published In: Volume - 2, Issue - 4, Year - 2009

View HTML

View PDF

ABSTRACT:
In this study the significant effect of recrystalline azithromycin alone and with hydrophilic polymers and surfactant were studied on improving the solubility, dissolution rate and other physicochemical properties by neutralization technique. The raw crystals of azithromycin was dissolved in the 0.1N HCl and poured the azithromycin solution into 0.1N NaOH solution. To the precipitated or recrystallized azithromycin immediately add the aqueous solution of different hydrophilic polymers like HPMC, PEG-6000, and surfactant like Poloxomer during the stirring process at room temperature. After 30 minutes add chloroform drop wise as bridging liquid for agglomeration of recrystallized azithromycin with polymers and surfactant. The pure azithromycin drug substance and prepared recrystallized agglomerates with polymers and surfactants were evaluated in terms of solubility, drug content, dissolution rate, flowability, wettability and packability. The raw azithromycin drug and prepared recrystallized agglomerates were characterized by thermal behavior (Differential Scanning Calirometry-DSC), X-ray powder diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The prepared recrystallized agglomerates with polymers HPMC and surfactant Poloxomer showed improvement in solubility, dissolution rates other physicochemical properties. The particle sizes of prepared recrystallized agglomerates were drastically reduced during precipitation process but increased after agglomeration with bridging liquid. The DSC showed reduced in the melting point enthalpy indicating disorder in the crystalline content. The XRD and FTIR also revealed a characteristic decrease in crystallinity and the chemistry of azithromycin in recrystallized agglomerates.

Keywords:

Cite this article:
AV Yadav, VB Yadav. Azithromycin Recrystallized Agglomerates with Hydrophilic Polymers and Surfactant by Neutralization Technique. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 796-802.

Recomonded Articles:

Medicinal Plants from Solanaceae Family

Author(s): Vishal Vilas Shah, Nutan Dhanpal Shah, Prasad Vasantrao Patrekar

DOI: Not Available Access: Open Access Read More

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9 Access: Open Access Read More

Dental Waxes–A Review

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5 Access: Open Access Read More

Prevalence of Kwashiorkor, Marasmus, Marasmic Kwashiorkor and Age wise Distribution of Malnourished Tribal Children of Town Dhadgaon, District-Nandurbar of Maharashtra State, India.

Author(s): Sangeeta Pingale, V.W. Patil , Mukesh Hire , Anita Katkade

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Fast Melt-Away Wafers Using Selected Polymers

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Curcumin and its Bioavailability Study

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8 Access: Open Access Read More

Formulation and Evaluation of Irbesartan nanosuspension for Dissolution Enhancement

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6 Access: Open Access Read More

Formulation Development and Characterization of Etodolac Loaded Transethosomes for Transdermal Delivery

Author(s): S. B. Gondkar, Neha R. Patil, R. B. Saudagar

DOI: 10.5958/0974-360X.2017.00541.8 Access: Open Access Read More

In-vitro cell line Models and Assay methods to study the Anti-diabetic Activity

Author(s): Justin Antony, Satadal Debroy, Chennu Manisha, Peet Thomas, Victoria Jeyarani, Tenzin Choephel

DOI: 10.5958/0974-360X.2019.00367.6 Access: Open Access Read More

Formulation and Development of a “Pressurised Metered Dose Inhalation” beclomethasone 250 mcg.

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available Access: Open Access Read More

Formulation and Evaluation of Transdermal Drug Delivery Systems of Ivabradine Hydrochloride

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available Access: Open Access Read More

Study of Leachate Characterization in Landfill by Municipal Solid Waste

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6 Access: Open Access Read More