Author(s): Chaple DR, Bhusari KP

Email(s): d.chaple@rediffmail.com

DOI: Not Available

Address: Chaple DR and Bhusari KP*
Sharad Pawar College of Pharmacy, Wanadongri, Higana Road, Nagpur-441 110 Maharashtra, India.
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
Simple UV and first derivative spectrophotometric methods have been developed for the determination of etoricoxib in tablet dosage form. In simple UV method, spectrum of etoricoxib in 0.1 N HCl showed absorbance maximum at 271.6 nm, where as in first derivative spectrum it shows maxima at 265.2 nm and minima at 301.6 nm. Beer’s law is obeyed over the concentration range 1-25µg/ml. The developed methods have been successfully applied for the determination of etoricoxib in tablet dosage form. The results obtained by the proposed methods were validated by recovery studies.


Cite this article:
Chaple DR, Bhusari KP. Spectrophotometric Methods for the Determination of Etoricoxib in Pharmaceutical Formulations. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 597-598.


REFERENCES:

1.       Cochrane DJ, Jarvis B and Keating GM. Adis new drug profile: etoricoxib. Drug.   2002; 62: 2637.

2.       Singh RM, Kumar Y, Sharma DK, Mathur SC, Singh GN, Ansari TA and Jamil S. Spectrophotometric method for the estimation of etoricoxib formulation. Indian Drugs. 2005; 42: 535.

3.       Suhagia BN, Patel HM, Shah SA, Rathod IS and Marolia BP. Spectrophotometric    estimation of etoricoxib in bulk and dosage forms. Indian  J.  Pharm. Sci. 2005; 67: 634.

4.       Ramakrishna NVS, Vishwottam KN, Wishu S and Koteshwara M. Validated liquid    chromatographic ultraviolet method for the quantitation of etoricoxib in human plasma using liquid–liquid extraction. J. of Chromatography B. 2005; 816: 215.

5.       Bräutigam L, Jens U. Nefflen JU and Geisslinger G. Determination of etoricoxib in human plasma by liquid chromatography–tandem mass spectrometry with electrospray ionization. J. of Chromatography B. 2003; 788: 309.

6.       Ansari TA, Jamil S, Singh RM, Mathur SC, Shivraj and Singh GN. Determination of etoricoxib in bulk drug and its dosage forms by RP HPLC. Indian Drugs. 2005; 42: 56.

7.       Mandal U, Rajan DS, Bose A, Gowda KV, Ghosh A and Pal T. K. Development and validation of an HPLC method for analysis of etoricoxib in human plasma. Indian J. Pharm. Sci. 2006; 68: 485.

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