Author(s): R Karthikeyan, B Thangabalan, A Elphine Prabahar, P Vijayaraj Kumar

Email(s): karthik_pharmd@yahoo.co.in

DOI: Not Available

Address: R Karthikeyan1*, B Thangabalan2, A Elphine Prabahar2 and P Vijayaraj Kumar3
1Vignan Pharmacy College, Vadlamudi, Guntur--522213. Andhra Pradesh.
2Department of Pharmacy, Donbosco PG College, Guntur, A.P, India.
3Bharat College of Pharmacy, Hyderabad, A.P, India.
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
Two simple and sensitive spectrophotometric methods (A and B) for the determination of imatinib in bulk drugs and pharmaceutical formulations are described. In method A, distilled water was used as solvent and shows absorbance maximum at 251 nm. In method B, 0.1 N HCL was used as solvent and shows absorbance maximum at 230 nm. In both the methods linearity was found to be in the range of 10 - 50 µg/ml; for method A (Y=0.0184 X+0.0061; r2=0.9992) and for method B (Y=0.0164 X-0.0032; r2=0.9997), respectively. These methods were tested and validated for various parameters according to USP guidelines. The quantitation limits were found to be 0.0334 and 0.0279 µg mL-1, for both the methods. The proposed methods were successfully applied for the determination of imatinib in pharmaceutical formulations. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation <2%), while being simple, cheap and less time consuming and can be suitably applied for the estimation of imatinib in different dosage forms.


Cite this article:
R Karthikeyan, B Thangabalan, A Elphine Prabahar, P Vijayaraj Kumar. New Spectrophotometric Methods for the Determination of Imatinib in Bulk Drug and in Pharmaceutical Formulations. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 578-581.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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