Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Preparation and Evaluation of Metformin Hydrochloride Microcapsules

Author(s): UD Shivhare, V Darakh, VB Mathur, KP Bhusari, MD Godbole

Email(s): udshivhare@gmail.com

DOI: Not Available

Address: UD Shivhare*, V Darakh, VB Mathur, KP Bhusari and MD Godbole
*Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110 *Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009

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ABSTRACT:
Metformin hydrochloride, an orally administered drug used to lower blood glucose level in patients with non-insulin dependent diabetes mellitus (NIDDM). Its plasma half-life is relatively short and requires frequent dosing. With this view, metformin hydrochloride microcapsules were prepared using hydrophobic polymers i.e. Eudragit S100, ethylcellulose, cellulose acetate by o/o solvent evaporation technique. Different batches of microcapsules were prepared by altering the drug: polymer ratio. Best optimized formula was evaluated for its drug polymer interaction by IR spectra, X-ray diffraction for any polymorphic changes. Scanning electron microscopy indicated that microcapsules prepared were discrete spherical and covered with continuous coating.


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Cite this article:
UD Shivhare, V Darakh, VB Mathur, KP Bhusari, MD Godbole. Preparation and Evaluation of Metformin Hydrochloride Microcapsules. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 559-562.

Cite(Electronic):
UD Shivhare, V Darakh, VB Mathur, KP Bhusari, MD Godbole. Preparation and Evaluation of Metformin Hydrochloride Microcapsules. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 559-562.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2009-2-3-75


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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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