Preparation and Evaluation of Metformin Hydrochloride Microcapsules

UD Shivhare; V Darakh; VB Mathur; KP Bhusari; MD Godbole

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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Preparation and Evaluation of Metformin Hydrochloride Microcapsules

Author(s): UD Shivhare, V Darakh, VB Mathur, KP Bhusari, MD Godbole

Email(s): udshivhare@gmail.com

DOI: Not Available

Address: UD Shivhare*, V Darakh, VB Mathur, KP Bhusari and MD Godbole
*Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110 *Corresponding Author

Published In: Volume - 2, Issue - 3, Year - 2009

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ABSTRACT:
Metformin hydrochloride, an orally administered drug used to lower blood glucose level in patients with non-insulin dependent diabetes mellitus (NIDDM). Its plasma half-life is relatively short and requires frequent dosing. With this view, metformin hydrochloride microcapsules were prepared using hydrophobic polymers i.e. Eudragit S100, ethylcellulose, cellulose acetate by o/o solvent evaporation technique. Different batches of microcapsules were prepared by altering the drug: polymer ratio. Best optimized formula was evaluated for its drug polymer interaction by IR spectra, X-ray diffraction for any polymorphic changes. Scanning electron microscopy indicated that microcapsules prepared were discrete spherical and covered with continuous coating.

Keywords:

Preparation and Evaluation of Metformin Hydrochloride Microcapsules.

Cite this article:
UD Shivhare, V Darakh, VB Mathur, KP Bhusari, MD Godbole. Preparation and Evaluation of Metformin Hydrochloride Microcapsules. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 559-562.

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